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230 studies found


Study phase: recruitment. For more details, see


APPROACH source cohorts

All baseline cohort parameters, clinical, conventional (knee x-ray and MRI and the robust biochemical markers), and novel markers (T2 relaxation MRI for cartilage collagen distribution, gagCEST MRI cartilage for proteoglycan content, knee CT/x-ray for bone shape and trabecular architecture, knee motion, and novel biochemical markers describing turnover of specific tissue component, as well as involvement of hand, hip and spine joint damage, hand joint inflammation, hip motion and shape and bo...


Activated T cell gene expression profile associated ...

T cells from PBMCs isolated from patients and healthy controls were in vitro activated with anti-CD3 and anti-CD28 for 72 hours. After T cell activation, cells were harvested and RNA extracted for microarray analysis.


Activation of mTOR controls the loss of TCRζ in lupu...

10 replicate T cell samples from SLE (Lupus) patients9 replicate T cell samples from healthy control (BC) subjects4 replicate Nitric Oxide (NOC-18) stimulated T cell samples from 4 of the control subjects4 replicate CD3/CD28 stimulated T cell samples from 4 of the control subjects


Activation of the Interferon Pathway is Dependent up...

Whole blood from 33 female SLE patients and 16 matched controls from EA and AA ancestral backgrounds was analyzed through Affymetrix Gene 1.0 ST gene expression arrays and the data were further studied through Ingenuity Pathways Analysis for canonical pathway comparison. An independent replication cohort of more than 100 SLE patient samples and 30 controls was used to test the hypotheses generated by the microarray data, using qPCR to quantify gene expression.


Airway epithelial gene expression in asthma versus h...

Gene expression comparisons were made between: 1. asthmatics and healthy controls, and 2. Th2 high asthma and Th2 Low asthma/Healthy controls. The gene expression alterations most associated with asthma were then used in gene set enrichment analyses and gene signature development to compare this asthma dataset to COPD gene expression datasets.


Altered gene expression pattern in peripheral blood ...

Twenty-eight patients with ST-segment elevation myocardial infarction (STEMI) were included. The blood was collected on the 1st day of myocardial infarction, after 4-6 days, and after 6 months. Control group comprised 14 patients with stable coronary artery disease (CAD), without history of myocardial infarction. Gene expression analysis was performed with Affymetrix GeneChip® Human Gene 1.0 ST microarrays and GCS3000 TG system.