Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

10 replicate T cell samples from SLE (Lupus) patients9 replicate T cell samples from healthy control (BC) subjects4 replicate Nitric Oxide (NOC-18) stimulated T cell samples from 4 of the control subjects4 replicate CD3/CD28 stimulated T cell samples from 4 of the control subjects


Primary Purpose
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Description of Cohorts
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Informed Consent Given?
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Multi-center Study?
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Organisms
Homo sapiens
Number of subjects
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Diseases
systemic lupus erythematosus
Sample Sources
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Type of Samples Collected
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Age Range of Study Participants
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BMI Range of Study Participants
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