Activation of the Interferon Pathway is Dependent upon Autoantibodies in African-American SLE Patients, but not in European-American SLE Patients

Whole blood from 33 female SLE patients and 16 matched controls from EA and AA ancestral backgrounds was analyzed through Affymetrix Gene 1.0 ST gene expression arrays and the data were further studied through Ingenuity Pathways Analysis for canonical pathway comparison. An independent replication cohort of more than 100 SLE patient samples and 30 controls was used to test the hypotheses generated by the microarray data, using qPCR to quantify gene expression.


Primary Purpose
-
Description of Cohorts
-
Informed Consent Given?
-
Multi-center Study?
-
Organisms
Homo sapiens
Number of subjects
-
Diseases
systemic lupus erythematosus
Sample Sources
-
Type of Samples Collected
-
Age Range of Study Participants
-
BMI Range of Study Participants
-