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7 studies found
Expression changes in mouse brains following nicotin...
Whole brain expression profiles were determined in two experimental groups of mice, sixteen mice that were not treated with nicotine and twelve mice one hour after experiencing nicotine-induced seizure. The untreated group included six wild-type mice, five alpha7+/T and five beta4-/- mice. The group of mice that underwent nicotine-induced seizures included three wild-types, five alpha7+/T and four beta4-/- mice. Different doses of nicotine were injected intraperitoneally (i.p.) to each genoty...
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Gene expression alterations in the cerebellum and gr...
The sample preparation and hybridzation of each cRNAs on GeneChip® Mouse Genome 430 2.0 arrays (Affymetrix, Santa Clara, CA, USA) were performed in Helsinki Biomedicum Biochip Center (Finland).
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HT-project: Expression profiling after prolonged exp...
Acute, short-, and long-term effects of prolonged febrile seizures on gene expression were investigated in whole hippocampal samples. Samples were taken from C57BL/6J animals one hour (HT n = 8, NT n = 8), three days (HT n = 6, NT n = 6), fourteen days (HT n = 6, NT n = 6), and fifty-six days (HT n = 6, NT n = 6) after HT. Two-channel oligonucleotide microarray analysis was performed with an NT and HT sample on the same chip, including a dye-swap (technical replicate). 3 failed hybridizations...
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Hippocampal gene expression signature following infl...
Inflammation-induced gene expression in the epileptic mouse hippocampus was measured at 4 and 24 hours after intraperitoneal injection of lipopolysaccharide (LPS; L5886, Sigma; from Salmonella enterica, serotype abortus equi; 100 micrograms/kg in PBS) or saline (SAL). Three animals per treatment group were analyzed at each time point (4 or 24 hours).
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Molecular consequences of Csf1R (M-CSF receptor) inh...
RNA was extracted from chronic epilepsy mouse hippocampi after 2 weeks daily exposure to vehicle, PLX3397 3mg/kg or 30 mg/kg. Healthy, non-epileptic mice, were added separately to determine baseline expression.
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Time-dependent transcriptomic profiles of mouse hipp...
40 animals were in the study; 80 samples were analyzed via Illumina beadchip microarray, a total which included 2 samples (IL and CL hippocampus) from each animal. Of the 80 samples,the n were as follows: IL-KA-7d, 8; CL-KA-7d, 8; IL-KA-28d, 9; CL-KA-28d, 9; IL-KA-60d, 9; CL-KA-60d, 9; IL-sham-7d, 4; CL-sham-7d, 4; IL-sham-28d, 5; CL-sham-28d, 5; IL-KA-60d, 5; CL-KA-60d, 5.
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whole brains from nicotinic acetylcholine receptor s...
The experimental groups included six wild-type mice and five beta4-/- mice. All mice were 6-9 weeks old. Total RNA was extracted from whole brain tissue of the mice.
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