Expression changes in mouse brains following nicotine-induced seizures; the modulation of transcription factor networks
Whole brain expression profiles were determined in two experimental groups of mice, sixteen mice that were not treated with nicotine and twelve mice one hour after experiencing nicotine-induced seizure. The untreated group included six wild-type mice, five alpha7+/T and five beta4-/- mice. The group of mice that underwent nicotine-induced seizures included three wild-types, five alpha7+/T and four beta4-/- mice. Different doses of nicotine were injected intraperitoneally (i.p.) to each genotype group of mice in order to achieve a similar seizure score in all three genotypes.
- Primary Purpose
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- Description of Cohorts
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- Informed Consent Given?
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- Multi-center Study?
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- Organisms
- Mus musculus
- Number of subjects
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- Diseases
- epilepsy
- Sample Sources
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- Type of Samples Collected
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