2 studies found
- observational (1)
- 3D cell cultures (0)
- Brightfield microscopy (0)
- Clinical trial (0)
- Clinical trial NCIT:C71104 (0)
- Drug discovery (0)
- Drug repurposing (0)
- MiRCOVID participants` samples and data for COVIRNA (0)
- PREDI-COVID participants` samples and data for COVIRNA (0)
- PROVID cohort of hospitalized COVID-19 patients (0)
Patients with MS or Clinically Isolated Syndrome (CIS) diagnosis according to McDonald criteria and who were prescribed IFN-beta-1a intramuscularly (IM), IFN-beta-1a subcutaneously (SC), or IFN-beta-1b SC (original product or biosimilar) were recruited from January 30, 2014 to January 22, 2016. Patients who were not naive to IFN-beta were excluded.
- Types: Observational
Data-mining and predictive modeling tools were utilized to analyze a gene-expression dataset of 94 non-treated patients; 62 patients with definite MS and 32 patients with clinically isolated syndrome (CIS). The dataset included the expression levels of 10,594 genes and annotated sequences corresponding to 22,215 gene-transcripts that appear in the microarray. We designed a two stage predictor. The first stage predictor was based on the expression level of 10 genes, and predicted the time to n...