Data Catalog

Genome-wide gene expression differences between Croh...

Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features and complex pathophysiologies. To identify pathogenic processes underlying these disease subtypes, using single endoscopic pinch biopsies to estabolish 36 expression profiles, we elucidated gene expression patterns of active and inactive areas of UC and CD, and compared these to infectious colitis and healthy controls.

Keywords: RNA expression profiling by array

161

Project website

Genomic predictor of response and survival following...

This SuperSeries is composed of the SubSeries listed below.

Keywords: NCBI GEO expression profiling by array

162

Project website

GetReal Initiative

The GetReal Initiative

Keywords: IMI projects Clinical trial design Real-world data, evidence Regulatory and HTA processes

163

Start: 2018-06-01
Project website

Global DNA methylation profiling of CD4+ T cells fro...

Systemic lupus erythematosus (SLE) is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we performed a genome-wide DNA methylation study in CD4+ T cells from 12 lupus patients and 12 normal healthy controls. Cytosine methylation was quantified in 27,578 CG pairs located within the promoter reg...

Keywords: NCBI GEO methylation profiling by array

164

Project website

Global gene expression profiles in whole blood total...

Patients with systemic lupus erythematosus are characterized by the spontaneous over-expression of interferon(IFN)-induced genes in peripheral blood RNA samples. In the present study, we wanted to study the evolution of the IFN gene signature in the peripheral blood of patients with lupus nephritis, before and after initiation of immunosuppressive therapy.Strikingly, we found that immunosuppressive therapy did not strongly reduce the expression of IFN-induced genes in patients who responded t...

Keywords: NCBI GEO expression profiling by array

165