Global gene expression profiles in whole blood total RNA from patients with lupus nephritis, before and after initiation of therapy

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Patients with systemic lupus erythematosus are characterized by the spontaneous over-expression of interferon(IFN)-induced genes in peripheral blood RNA samples. In the present study, we wanted to study the evolution of the IFN gene signature in the peripheral blood of patients with lupus nephritis, before and after initiation of immunosuppressive therapy.Strikingly, we found that immunosuppressive therapy did not strongly reduce the expression of IFN-induced genes in patients who responded to therapy, as indicated by decreased general and renal indices of disease activity. By contrast, the IFN gene signature decreased in patients developing renal failure.

keywords: NCBI GEO expression profiling by array

General Project Information

Project website: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA294806
Start date: -
End date: -
Funding: -
Types: NCBI GEO
Project publications: https://pubmed.ncbi.nlm.nih.gov/27354683

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Study	Datasets
Global gene expression profiles in whole blood total RNA from patients with lupus nephritis, before and after initiation of therapy	Global gene expression profiles in whole blood total RNA from patients with lupus nephritis, before and after initiation of therapy