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134 projects found
Genome-wide analysis of atypical NK cell subset in m...
Exploratory study to identify genome-wide changes in expression between conventional NK cells isolated from B6 WT and NK1.1+ cells from TLR7tg mice
Keywords: NCBI GEO expression profiling by array
65
Genomic predictor of response and survival following...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
66
Global gene expression profiles in whole blood total...
Patients with systemic lupus erythematosus are characterized by the spontaneous over-expression of interferon(IFN)-induced genes in peripheral blood RNA samples. In the present study, we wanted to study the evolution of the IFN gene signature in the peripheral blood of patients with lupus nephritis, before and after initiation of immunosuppressive therapy.Strikingly, we found that immunosuppressive therapy did not strongly reduce the expression of IFN-induced genes in patients who responded t...
Keywords: NCBI GEO expression profiling by array
67
HT-project: Expression profiling after prolonged exp...
Febrile seizures are the most prevalent type of seizures among children up to 5 years of age (2-4% of Western-European children). Complex febrile seizures are associated with an increased risk to develop temporal lobe epilepsy. To investigate short- and long-term effects of experimental febrile seizures (eFS), we induced eFS in highly febrile convulsion-susceptible C57BL/6J mice at post-natal day 10 by exposure to hyperthermia (HT) and compared them to normotherm-exposed (NT) mice. We detecte...
Keywords: NCBI GEO expression profiling by array
68
Hippocampal gene expression signature following infl...
We used a systemic inflammatory challenge in animals with chronic mesial temporal lobe epilepsy to identify novel molecular pathways involved in seizure regulation. Mice were first rendered epileptic by a single intrahippocampal injection of kainic acid (KA). After a period of two-three weeks, mice developed spontaneous seizures and then received a single intraperitoneal injection of lipopolysaccharide (LPS) to mimic systemic inflammation, or saline as a control. Gene expression analysis by m...
Keywords: NCBI GEO expression profiling by array
69
Human Rheumatoid Arthritis Synovial Fibroblasts: Con...
Transcriptional profiling of human rheumatoid arthritis synovial fibroblasts comparing control cells treated with BSA with cells treated with Tenascin-C.
Keywords: NCBI GEO expression profiling by array
70
Human bone marrow-derived mononuclear cells (BMMC): ...
Gene expression profiling of BMMC from patients with rheumatoid arthritis (RA) vs. osteoarthritis (OA).
Keywords: NCBI GEO expression profiling by array
71
Human keratinocytes have a response to injury that u...
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive immune responses, e.g. CCL20, in their early state of activation without signals from infiltrating T cells. This study aims to isolate the immediate alterations in protective and inflammatory gene ...
Keywords: NCBI GEO expression profiling by array
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