Data Catalog

chronic temporal lobe epilepsy: biopsy hippocampus

Analysis of biopsy hippocampal tissue of patients with pharmacoresistant temporal lobe epilepsy (TLE) undergoing neurosurgical removal of the epileptogenic focus for seizure control. Chronic TLE goes along with focal hyperexcitability. Results provide insight into molecular mechanisms that may play a role in seizure propensity

Keywords: NCBI GEO expression profiling by array

Project website

Genome-wide analysis of atypical NK cell subset in m...

Exploratory study to identify genome-wide changes in expression between conventional NK cells isolated from B6 WT and NK1.1+ cells from TLR7tg mice

Keywords: NCBI GEO expression profiling by array

Project website

Childhood Atopic Asthma

This SuperSeries is composed of the SubSeries listed below.

Keywords: NCBI GEO expression profiling by array methylation profiling by array

Project website

Time-dependent transcriptomic profiles of mouse hipp...

Mesial Temporal Lobe Epilepsy (MTLE) is a chronic disease characterized by recurrent unprovoked partial seizures. Current treatments lack long-term efficacy and typically act only to ameliorate the symptomology, rather than to modify the course of the disease. Chronic kainic acid (KA)-induced models of MTLE mimic prominent histopathological and electroencephalographic features of human MTLE, including hippocampal sclerosis, CA1 neuronal loss, astrogliosis, microgliosis, and electrographic hip...

Keywords: NCBI GEO expression profiling by array

Project website

Down-regulation of Interferon signature in systemic ...

Interferon-alpha Kinoid (IFN-K) is a therapeutic vaccine composed of IFN-alpha2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients (see GSE39088). Here, we analyzed extended follow-up data from IFN-K-treated patients, in terms of persistence of neutralizing anti-IFN± Abs, gene expression profiling and safety.Follow-up analyses in six patients confirmed a sig...

Keywords: NCBI GEO expression profiling by array

Project website

Global gene expression profiles in whole blood total...

Patients with systemic lupus erythematosus are characterized by the spontaneous over-expression of interferon(IFN)-induced genes in peripheral blood RNA samples. In the present study, we wanted to study the evolution of the IFN gene signature in the peripheral blood of patients with lupus nephritis, before and after initiation of immunosuppressive therapy.Strikingly, we found that immunosuppressive therapy did not strongly reduce the expression of IFN-induced genes in patients who responded t...

Keywords: NCBI GEO expression profiling by array

Project website

Molecular consequences of Csf1R (M-CSF receptor) inh...

Efficacy of Csf1R inhibition by PLX3397 compound in a mouse model of chronic epilepsy has been assessed by daily administration of either vehicle, 3 mg/kg or 30 mg/kg during 2 weeks monitoring. At the end of the study, RNA was extracted from study animals hippocampi to assess treatment consequences at the gene expression level in view of the in vivo efficacy results and the previously identified consequences of epilepsy in hyppocampus. Naive healthy mice were added separately to determine bas...

Keywords: NCBI GEO expression profiling by array