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235 studies found
Global DNA methylation profiling of CD4+ T cells fro...
We employed microarray-based technologies to perform a genome-wide DNA methylation assay and quantify CD4+ T cell DNA methylation levels at 27,578 CG sites spanning 14,495 genes of 11 lupus patients and 12 healthy controls.
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Global gene expression profiles in whole blood total...
Global gene expression studies were performed in serial whole blood samples from SLE patients with a renal BILAG A prior to, 3 months, and 6 months after initiation of conventional immunosuppressive therapy (induction with high-dose corticosteroids, IV cyclophosphamide or oral mycophenolate during the first 3 months, followed by maintenance with moderate- to low-dose corticosteroids, azathioprine or mycophenolate). The expression of IFN-induced genes was analyzed, in comparison to global and ...
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HT-project: Expression profiling after prolonged exp...
Acute, short-, and long-term effects of prolonged febrile seizures on gene expression were investigated in whole hippocampal samples. Samples were taken from C57BL/6J animals one hour (HT n = 8, NT n = 8), three days (HT n = 6, NT n = 6), fourteen days (HT n = 6, NT n = 6), and fifty-six days (HT n = 6, NT n = 6) after HT. Two-channel oligonucleotide microarray analysis was performed with an NT and HT sample on the same chip, including a dye-swap (technical replicate). 3 failed hybridizations...
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Hippocampal gene expression signature following infl...
Inflammation-induced gene expression in the epileptic mouse hippocampus was measured at 4 and 24 hours after intraperitoneal injection of lipopolysaccharide (LPS; L5886, Sigma; from Salmonella enterica, serotype abortus equi; 100 micrograms/kg in PBS) or saline (SAL). Three animals per treatment group were analyzed at each time point (4 or 24 hours).
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Human Chronic Obstructive Pulmonary Disorder (COPD) ...
We assessed genome-wide expression patterns in lung tissue specimens derived from 56 subjects. These subjects were undergoing lobectomy for removal of a suspected tumor, and tissue for our studies was derived from histologically normal tissue distant from the tumor margin. Subjects underwent routine spirometry prior to surgery. Low values for both FEV1 and FEV1/FVC are characteristic features of COPD and associated with the severity of disease. For our studies, Cases (n=15) were defined as...
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Human Rheumatoid Arthritis Synovial Fibroblasts: Con...
Two-condition experiment, BSA vs. Tenascin-C stimulated cells. One replicate per array.
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Human bone marrow-derived mononuclear cells (BMMC): ...
Bone marrow was obtained from patients with RA (n=9) or OA (n=10). The bone marrow samples from the 10 OA patients are used as controls.
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