Data Catalog

Expression data from mouse bone marrow macrophages f...

Expression QTLs and sex effects on gene expression and eQTLs were determined

Expression data from peripheral blood - blood draws...

Blood was collected immediately prior to, and two hours after challengeThe change in gene expression (post expression minus pre expression) in ERs was compared with the change in gene expression in DRs using age and sex as covariatesPreprocessing and probeset filtering were applied to the entire dataset (28 CEL files) using the Factor Analysis for Robust MicroArray Summarization (farms) package in RThe Linear Models for MicroArrays (limma) package was used to determine differential gene expre...

Expression data from primary human keratinocytes exp...

Primary keratinocytes from three donors (subjects 1, 2, and 3) were obtained and were either untreated (control) or exposed to cytokines (IL-4, IL-13, IFN-alpha, IFN-gamma and TNF). For the IL17A samples, primary keratinocytes were obtained from six donors, with cells derived from three donors treated with IL-17A and cells derived from the other three donors left untreated (i.e., unpaired control samples).

Expression data from skin biopsy samples from patien...

Skin biopsy samples (n=170) were collected at baseline for RNA extraction and microarray analysis from 85 patients with moderate-to-severe psoriasis without receiving active psoriasis therapy. The sample title is concatenated as <sample collection site ID>_<subject ID>_<skin type>.

Expression data of substantia nigra from postmortem ...

Substantia nigra tissue from postmortem brain of normal and Parkinson disease patients were used for RNA extraction and hybridization on Affymetrix microarrays: 9 replicates for the controls and 16 replicates for the Parkinson's disease patients were used. Both cohorts included males and females.

Expression data of synovial cells isolated from pati...

We isolated synovial cell culture from patients with rheumatoid arthritis and osteoarthritis. Fibroblast from patient with osteoarthritis was used for the reference.

Gene Expression Analysis in Peripheral Blood of Pati...

The measurement of expression level of several genes shown below in peripheral blood of human subjects (18 patients with rheumatic disease) before and after tocilizumab medication using DNA microarray (Hitachi human oligo chip) was conducted in this test,1) Interleukin 6 (IL-6), membrane IL-6 receptor (IL-6R) and soluble type of the IL-6R,2) several cytochrome P450 as follows: CYP3A4, CYP2D6, CYP2C9, CYP2C19.Number of human subjects was 18 and peripheral blood samples drawn at 4 time points:d...

Gene Expression Profiles in a Rabbit Model of System...

An important goal of biomedical research is to translate basic findings into clinical applications. Models in inbred mice that spontaneously develop SLE, along with various mutant, transgenic and knockout models have documented a variety of genetic defects leading to SLE, but from the clinical perspective, the degree to which these findings using the inbred or homogeneous artificially mutated strains apply to individuals in heterogeneous outbred human populations is open to question. Given th...