Data Catalog

Expression data from human skin biposies (lesional a...

Comparative RNA expression profiles from uninvolved and lesional skin of 13 patients with mild to severe plaque-type psoriasis.

Expression data from primary human keratinocytes exp...

Primary keratinocytes from three donors (subjects 1, 2, and 3) were obtained and were either untreated (control) or exposed to cytokines (IL-4, IL-13, IFN-alpha, IFN-gamma and TNF). For the IL17A samples, primary keratinocytes were obtained from six donors, with cells derived from three donors treated with IL-17A and cells derived from the other three donors left untreated (i.e., unpaired control samples).

Expression data from skin biopsy samples from patien...

Skin biopsy samples (n=170) were collected at baseline for RNA extraction and microarray analysis from 85 patients with moderate-to-severe psoriasis without receiving active psoriasis therapy. The sample title is concatenated as <sample collection site ID>_<subject ID>_<skin type>.

Gene expression data of skin from psoriatic patients...

We extracted total RNA from punch biopsies taken from 58 psoriatic patients and 64 normal healthy controls. Two biopsies were taken from each patient; one 6mm punch biopsy was obtained from lesional skin of each patient (involved sample) and the other from non-lesional skin (uninvolved sample), taken at least 10 cm away from any active plaque. One biopsy was obtained from each healty control. Totally 180 samples were run on Affymetrix HU133 Plus 2.0 microarrays containing >54,000 gene probes....

Gene expression in psoriasis lesions and uninvolved skin

Four individuals with chronic plaque psoriasis were enrolled. 6 mm punch biopsies were obtained under local anaesthesia (lidocaine) from uninvolved skin and a target plaque.

Gene expression profiles in synovial biopsies from p...

GeneChip® Human Genome U133 Plus 2.0 Arrays (Affymetrix UK Ltd., High Wycombe, UK) were hybridized in monoplicates with 10 μg biotinylated cRNA, using synovial biopsy samples obtained in 4 patients with SA (based on the presence of psoriasis or x-ray evidence of sacro-iliacal joint involvement), 5 patients with MIC, based on the identification of urate or calcium pyrophosphate crystals in the synovial fluid, 7 patients with RA (ACR 1987 criteria), 4 patients with SLE (ACR criteria) and 5 pati...

Gene expression profiling in psoriatic lesional and ...

From each of the 25 psoriasis patients, we obtained two pre-dose biopsies, one from a lesion and the other from non-lesional skin in the same general body geography, and two post-dose biopsies. Total RNA was extracted from 6mm punch biopsies that were split in half. A total of 99 samples were run on Affymetrix HU133 Plus 2.0 microarrays. There was no paired non-lesional sample for 'T_lesional_pre-dose' (skn55789).