Search studies
15 studies found
Human colon expression in healthy, CD, treated CD, and UC
Colon RNA was isolated from biopsies obtained from CD at diagnosis and during therapy, UC at diagnosis, and healthy controls. Samples were obtained from the most proximal affected segment of colon. Microarray experiments were performed as described in the CCHMC microarray core, and data was analyzed as described above in the summary.The '107' internal control CEL files (for batches 1-4) used for normalization of the Sample VALUEs are linked below as supplementary files.
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Molecular patterns in human ulcerative colitis and c...
We studied 56 colon biopsies from patients with colitis, including 43 with UC, characterizing the clinical and histological features, and defined the mRNA phenotype with Affymetrix expression microarrays. We measured the expression of previously defined pathogenesis-based transcript sets representing effector T cells, macrophages, IFNG effects, and parenchymal injury response and dedifferentiation. We also studied 48 microarray files from human colon biopsies from the Gene Expression Omnibus ...
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Mucosal expression profiling in patients with inflam...
Mucosal biopsies were obtained at endoscopy in actively inflamed mucosa from 61 IBD patients (24 ulcerative colitis (UC), 19 Crohn’s colitis (CDc) and 18 Crohn’s ileitis (CDi)), refractory to corticosteroids and/or immunosuppression, before and 4-6 weeks after (except for 1 CDc patient) their first infliximab infusion and in normal mucosa from 12 control patients (6 colon and 6 ileum). The patients were classified for response to infliximab based on endoscopic and histologic findings at 4-6 w...
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Mucosal gene expression profiling in (un)inflamed co...
Colonic mucosal biopsies were obtained during endoscopy from 13 UC (7 active and 6 inactive) patients and 8 normal controls. Total RNA was isolated from colonic mucosal biopsies, labelled and hybridized to Affymetrix Genechip Human Gene 1.0ST Arrays.
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Mucosal miRNA expression profiling in (un)inflamed c...
Colonic mucosal biopsies were obtained during endoscopy from 17 UC (10 active and 7 inactive) patients and 10 normal controls. Total RNA, including small RNA, was isolated from colonic mucosal biopsies, labelled and hybridized to Affymetrix Genechip miRNA 2.0 Arrays.
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Transcriptional analysis of left-sided colitis, panc...
Colonic biopsies were obtained from forty-five patients with UC (20 left-sided colitis, 19 pancolitis, and 6 UC-associated dysplasia) and 15 controls. The Affymetrix GeneChip Human Genome U133 Plus 2.0 was used
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