Search studies
21 studies found
Hippocampal gene expression signature following infl...
Inflammation-induced gene expression in the epileptic mouse hippocampus was measured at 4 and 24 hours after intraperitoneal injection of lipopolysaccharide (LPS; L5886, Sigma; from Salmonella enterica, serotype abortus equi; 100 micrograms/kg in PBS) or saline (SAL). Three animals per treatment group were analyzed at each time point (4 or 24 hours).
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Molecular consequences of Csf1R (M-CSF receptor) inh...
RNA was extracted from chronic epilepsy mouse hippocampi after 2 weeks daily exposure to vehicle, PLX3397 3mg/kg or 30 mg/kg. Healthy, non-epileptic mice, were added separately to determine baseline expression.
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Polyglutamine Atrophin provokes neurodegeneration in...
Neurodegeneration progression caused by poly glutamine expansions of the Atro gene is measured by mRNA expression profiles in 4 D.melanogaster genotypes: in wild-type animals (controls), animals constitutively expressing the wild-type Atro transgene, animals constitutively expressing the polyQ expanded Atro transgenes A66QC and A75QN. The expressions of the Atro genes are under a GMR-Gal4 driver repressed by a Gal80 universal repressor sensitive to temperature. When flies are raised at 18 C, ...
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Rat exposure to RDX (3mg/kg or 18mg/kg; 0, 4, 24, 48 hr)
Male Sprague-Dawley rats were given a single, oral, non-seizure inducing dose of either 3 or 18 mg/kg RDX in a gel capsule. Rats were euthanized at times 0, 4, 24, and 48 hours. RNA purified from brain cortex or liver was hybridized to Affymetrix rat 230.2 arrays.
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Rat model of MTLE: Animals with epilepsy vs animals ...
Four condition experiment with five samples per condition. The samples include right dentate gyrus from animals with seizures, left dentate gyrus from animals with seizures, right dentate gyrus from animals without seizures, and left dentate gyrus from animals without seizures. A dye swap was included.
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Time course microarray data following GR activation ...
MCF10A-Myc cells were subjected to 72 hrs of growth factor withdrawal followed by treatment with either vehicle (ethanol) or Dex (10-6 M) for 0.5, 2, 4 or 24 hrs. Total RNA from each sample was extracted using Qiagen’s RNeasy Kit. Preparation of biotinylated cRNA and hybridization to oligonucleotide arrays (Affymetrix human genome genechip HG-U133A) were performed at the University of Chicago Microarray Core Facility. HG-U133A genechip contains 22,215 probe sets that represent approximatel...
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