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16 studies found
Systematic meta-analysis and replication of genome-w...
Substantia nigra samples from 6 PD and 5 control subjects were obtained. At autopsy, brain hemispheres were frozen in liquid nitrogen and stored at -80C in the Kathleen Price Bryan Brain Bank in the Alzheimer's Disease Research Center at Duke University. Using the RNAgents kit (Promega, Madison, Wis), RNA was extracted from SN and adjacent midbrain tissues. Double-stranded complementary DNA was made with a biotinylated T7(dT)-24 primer. Twenty micrograms of biotinylated complementary RNA was ...
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Systematic meta-analysis and replication of genome-w...
Fresh frozen tissue blocks from cerebellar hemispheres of PD patients and controls were provided by the Queens Square Brain Bank for Neurological Disorders (London, UK). Total RNA was isolated from about 500 mg fresh frozen postmortem tissue from each subject by using Trizol reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer's protocol and further purified using the RNeasy mini kit (Qiagen, Hilden, Germany). Quality of the extracted total RNA was assessed using an Agilent 2...
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Systems-based analyses of brain regions functionally...
Substantia Nigra (3 normal, 3 PD), Striatum (6 normal, 6 PD), Cortex (5 normal, 5 PD), Cortex non-PD neurodegeneration (2 normal, 3 DLB).Note Sample X201264 was used both for Cortex normal and for Cortex nonPD normal
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Transcriptional analysis of prefrontal area 9 in Par...
Published work contains more information on Parkinson and Control groups
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Transcriptional analysis of putamen in Parkinson's disease
Published work contains more information on Parkinson and Control groups.Samples GSM606619-GSM606623 are not included in the dataset described in PMID 15965975.
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Transcriptional analysis of whole substantia nigra i...
Published work contains more information on Parkinson and Control groups.Samples GSM606624-GSM606626 are not included in the dataset described in PMID 15965975.
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Transcriptome analysis of a chronic in vitro model o...
SK-N-MC cells were grown in three different conditions: media + vehicle (EtOH), media + a sublethal dose (5 nM) of rotenone, and media + a slightly toxic dose (50 nM) of rotenone. Gene expression was examined at 1 and 4 weeks of rotenone treatment. Three experiments were performed, each lasting 1 and 4 weeks. For each experiment, 5 separate dishes of vehicle-treated, and rotenone-treated cells were harvested at 1 and 4 weeks (30 independent samples at each time point) and pooled into 3 s...
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