Search projects

Expression changes in mouse brains following nicotin...

Nicotine, acting through the neuronal nicotinic acetylcholine receptors (nAChR), can induce seizures in mice. We aimed to study brain transcriptional response to seizure and to identify genes whose expression is altered after nicotine-induced seizures. Whole brains of untreated mice were compared to brains one hour after seizure activity, using Affymetrix U74Av2 microaarays. Experimental groups included wild-type mice and both nicotine-induced seizures sensitive and resistant nAChR mutant mic...

Keywords: treatment seizure activity genotypes expression profiling by array

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Prediction of acute multiple sclerosis relapses by t...

Background: The ability to predict the spatial frequency of relapses in multiple sclerosis (MS) would enable treating physicians to decide when to intervene more aggressively and to plan clinical trials more accurately. Methods: In the current study our objective was to determine if subsets of genes can predict the time to the next acute relapse in patients with MS. Data-mining and predictive modeling tools were utilized to analyze a gene-expression dataset of 94 non-treated patients; 62 pat...

Keywords: Disease prediction expression profiling by array

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Expression data from affected skin from psoriasis mo...

Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. In this study, whole-genome transcriptional profiling is used to compare gene expression p...

Keywords: NCBI GEO expression profiling by array

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The Nasal Methylome and Childhood Atopic Asthma

Background: Nasal epithelia are emerging as a proxy measure of gene expression of the airway epithelium in asthma. We hypothesized that epigenetic marks regulate gene expression of the nasal epithelia and consequently may provide a novel target for allergic asthma. Methods: We compared genomic DNA methylation patterns and gene expression in African American children with persistent atopic asthma [N=36] versus healthy controls [N=36]. Results were validated in an independent populatio...

Keywords: NCBI GEO methylation profiling by array

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ImmUniverse

Immuniverse research projects at LCSB aim at to better control and treatment of immune-mediated diseases by exploring the universe of microenvironment-imposed tissue signatures and their correlates in liquid biopsies. The precise aims of the ImmUniverse project are given below: Objective 1. Comprehensive molecular characterization of intestinal/dermal microenvironment and immune cell profiles that provides a data foundation for advanced bioinformatics, statistical and model-based analysis. ...

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