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185 projects found
Expression data from mouse bone marrow macrophages f...
Bone marrow macrophages were cultured from 16 week old apoE-deficient F2 mice from an AKRxDBA/2 intercrossGene expression profiling was performed using Affy 430v2 arrays, and 1967 informative SNP markers were genotyped for each mouseSupplementary file of SNP data attached below from ParAllele 5K mouse linkage panel
Keywords: Genetic-genomic macrophages expression profiling by array
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Expression data from peripheral blood - blood draws...
To determine differential gene expression in peripheral blood of asthmatic individuals undergoing allergen inhalation challenge between early responders (ERs) and dual responders (DRs) following allergen inhalation challenge
Keywords: NCBI GEO expression profiling by array
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Expression data from primary human keratinocytes exp...
The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response between individual patients, and this may reflect heterogeneity of inflammatory networks driving the disease. In this study, whole-genome transcriptional profiling was used to characterize inflammatory and cytokine networks in 62 lesional skin sample...
Keywords: NCBI GEO expression profiling by array
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Expression data from skin biopsy samples from patien...
A gene expression profiling sub-study was conducted in which skin biopsy samples were collected from 85 patients with moderate-to-severe psoriasis who were participating in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial. This analysis identified 4,175 probe-sets as being significantly modulated in psoriasis lesions (LS) compared with matched biopsies of non-lesional (NL) skin.
Keywords: NCBI GEO expression profiling by array
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Expression data of substantia nigra from postmortem ...
We used microarrays to detail the global program of gene expression underlying Parkinson's disease
Keywords: normal versus diseased expression profiling by array
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Expression data of synovial cells isolated from pati...
Rheumatoid arthritis (RA), a chronic and systemic disease of unknown etiology, is characterized by hyperplasia of synovial cells, which ultimately lead to the destruction of cartilage and bone. To elucidate the molecular mechanisms that lead to RA, we analyzed synovial cells established from patient with RA by oligonucleotide microarrays. Gene expression profiles reveal a novel pathophysiologic function of RA synovial cells as a generator of oxidative stress, and a self-defense mechanism ag...
Keywords: cell type comparison disease state analysis expression profiling by array
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Gene Expression Analysis in Peripheral Blood of Pati...
Peripheral blood cells in patients with rheumatoid arthritis before/after IL-6 inhibitionThe obtained conclusions on the change of each gene expression level before and after MRA medication were as follows.(1) In the case of IL-6, the specific time profile that the expression level dropped at day 21 and increased to some extent at day 42 was observed in 2 of 18 subjects. In other subjects, quite small change or small increase after day 7 was observed.(2) In the case of IL-6R as well as in IL-...
Keywords: NCBI GEO expression profiling by array
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Gene Expression Profiles in a Rabbit Model of System...
We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model of Systemic Lupus Erythematosus (SLE) in which peptide immunization led to lupus-like autoantibody production including anti-Sm, -RNP, -SS-A, -SS-B and -dsDNA. Some neurological symptoms in form of seizures and nystagmus were observed. The animals used in the previous and in the present study were from a National Institute of Allergy and Infectious Diseases colony of rabbits that were pedigreed, immunoglobulin...
Keywords: NCBI GEO expression profiling by array
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