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185 projects found
Whole genome transcription and DNA methylation analy...
Our study has demonstrated that significant number of differential genes in SLE was involved in IFN, TLR signaling pathways and inflammatory cytokines. The enrichment of differential genes has been associated with aberrant DNA methylation, which may be relevant to the pathogenesis of SLE. Our observations laid the groundwork for further diagnostic and mechanistic studies of SLE and LN.
Keywords: NCBI GEO methylation profiling by genome tiling array
177
Whole transcriptome analysis of the hippocampus: tow...
Purpose: to evaluate changes in the transcriptome of hippocampal cells during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures.Experimental Design: Gene expression profiling was analyzed in hippocampi of rats subjected to the pilocarpine model of epilepsy at different times during the course of epileptogenesis: 3 days post-SE (3D), 7 days post-SE (7D), and immediately (up to 12h) after the first spontaneous seizur...
Keywords: gene expression changes during epileptogenesis. expression profiling by array
178
ZNF750 in late keratinocyte differentiation
Disrupted skin barrier due to altered keratinocyte differentiation is common in pathologic conditions such as atopic dermatitis, ichthyosis and psoriasis. However, the molecular cascades governing keratinocyte terminal differentiation are still poorly understood. We have previously demonstrated that a dominant mutation in ZNF750 leads to a clinical phenotype that reminiscent of psoriasis and seborrheic dermatitis. We defined ZNF750 as a nuclear effector that is strongly activated in and essen...
Keywords: NCBI GEO expression profiling by array
179
asthma
Bronchial Epithelial Cells were isolated processed as described (Chu et al., 2002 and Zhao et al., 2011). The objective of the study was to identify differentially expressed genes between normal control (NC), mild-moderate asthmatic (MMA) and severe asthmatic (SA) patients.
Keywords: NCBI GEO expression profiling by array
180
chronic temporal lobe epilepsy: biopsy hippocampus
Analysis of biopsy hippocampal tissue of patients with pharmacoresistant temporal lobe epilepsy (TLE) undergoing neurosurgical removal of the epileptogenic focus for seizure control. Chronic TLE goes along with focal hyperexcitability. Results provide insight into molecular mechanisms that may play a role in seizure propensity
Keywords: NCBI GEO expression profiling by array
181
expression profiling of responsiveness to infliximab...
Identifying gene expression profiles as predictors of a good vs poor response to a combined infliximab/methotrexate treatment in rheumatoid arthritis patients.
Keywords: drug response expression profiling by array
182
expression profiling of rheumatoid arthritis patient...
Expression profiles of anti-TNF responders were compared to profiles of anti-TNF non-responders in order to identify an expression signature for anti-TNF response
Keywords: NCBI GEO expression profiling by array
183
isolated alveolar macrophages
This series represents isolated alveolar macrophages from human subjects.
Keywords: parallel sample expression profiling by array
184
