Search projects
142 projects found
Restoration of regulatory and effector T cell balanc...
Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably the expansion of Tregs and the decrease of Th1 and Th17 cells. A significant correlation between higher disease activity and lower serum 25-hydroxyvitamin D levels was also shown.This preliminary s...
Keywords: NCBI GEO expression profiling by array
105
Reversal of Atopic Dermatitis with Narrow-Band UVB P...
Background: Atopic dermatitis (AD) is a common inflammatory skin disease exhibiting a predominantly Th2/“T22” immune activation and a defective epidermal barrier. Narrow-band UVB (NB-UVB) is considered an efficient treatment for moderate to severe AD. In psoriasis, NB-UVB has been found to suppress the Th1/Th17 immune polarization with subsequent reversal of epidermal hyperplasia. The immunomodulatory effects of this treatment are largely unknown in AD. Our study evaluates the effects of NB-U...
Keywords: NCBI GEO expression profiling by array
106
Rheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from the Stanford Functional Genomics Facility (http://microarray.org/sfgf/) printed on aminosilane-coated slides containing ~20.000 unique genes. Only one batch of arrays was used for all experiments. Fi...
Keywords: NCBI GEO expression profiling by array
107
Short-term exposure to diesel exhaust is associated ...
DNA methylation in asthmatics after short-term exposure to diesel exhaust
Keywords: NCBI GEO methylation profiling by array
108
Similarities and differences in the transcriptome of...
Phenotypic and functional diversity between macrophage subpopulations reflects their plasticity to respond to microenvironmental signals. Apart from detecting differences in expression profiles, the comparison of the transcriptomes of different macrophage populations may also allow the definition of molecular similarities between these subsets.Transcriptome analysis of human Kuppfer cells, alveolar, splenic and atherosclerotic plaque residing macrophages using microarrays, identified 42 genes...
Keywords: NCBI GEO macrophages expression profiling by array
109
Sputum gene expression profiling in asthmatics
Gene expression profiling was performed on sputum samples obtained from asthmatics and matched healthy controls, to identify markers associated with various asthma subtypes.
Keywords: NCBI GEO expression profiling by array
110
Systematic meta-analysis and replication of genome-w...
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.Examination of substantia nigra from postmortem brains of 8 patients with Parkinson's disease (PD).
Keywords: NCBI GEO expression profiling by array
111
Systematic meta-analysis and replication of genome-w...
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.Analysis of substantia nigrae from postmortem brains of 6 patients with Parkinson's disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.
Keywords: NCBI GEO expression profiling by array
112
