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375 projects found
Circulating Mononuclear Cell Transcriptomes in Patie...
Monocytes and T-cells play an important role in the development of atherosclerotic coronary artery disease (CAD). Differences in transcriptional activity of these cells might reflect the individual's atherosclerotic burden. Transcriptome analysis of circulating mononuclear cells from carefully matched atherosclerotic and control patients will potentially provide insights into the pathophysiology of atherosclerosis and supply biomarkers for diagnostic purposes. From patients undergoing coron...
Keywords: disease-state analysis macrophages expression profiling by array
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Colon biopsies from Crohns patients and healthy controls
The aim of this study was to investigate differential intestinal gene expression in patients with Crohn's disease (CD) and controls. 172 biopsies from CD and control subjects were studied. Endoscopic biopsies were taken at ileocolonoscopy from five specific anatomical locations including the terminal ileum for RNA extraction.
Keywords: NCBI GEO expression profiling by array
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Combination of peripheral blood gene expression prof...
We used microarrays to identify markers predicting responder status in tocilizumab treatment in rheumatoid arthritis in 13 patients at week 0 and week 4 of treatment.
Keywords: NCBI GEO expression profiling by array
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Comparison of PBMCs in Inflammatory Bowel Disease
Comparison of PBMC transcriptional profiles in healthy subjects, patients with Crohn's Disease, and patients with Ulcerative Colitis
Keywords: Disease state expression profiling by array
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Comparison of human Rheumatoid arthritis patient per...
Leukocytapheresis((LCAP) is a safe, unique therapy prevalent for intractable rheumatoid arthritis even in case of drug allergy or infectious state. To investigate how to improve LCAP efficacy, we have conducted genes expressions analysis from peripheral blood of Rheumatoid arthritis patients using high resolution DNA microarray just before and after LCAP procedure.
Keywords: NCBI GEO expression profiling by array
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Comparison of mRNA expression in circulating T-cells...
Comparison of mRNA expression showed widespread changes in the circulating CD8+ but not CD4+ T-cells from patients with severe asthma. No changes were observed in the CD4+ and CD8+ T-cells in non-severe asthmatics versus healthy controls. Bioinformatics analysis showed that the changes in CD8+ T-cell mRNA expression were associated with multiple pathways involved in T-cell activation. As with mRNAs, we also observed widespread changes in expression of non-coding RNA species including natural ...
Keywords: NCBI GEO expression profiling by array
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ConcePTION
Building an ecosystem for better monitoring and communicating of medication safety in pregnancy and breastfeeding: validated and regulatory endorsed workflows for fast, optimised evidence generation
Keywords: IMI projects Tools for predicting/monitoring safety Biobanks Big data and knowledge management Real-world data, evidence Tools for pediatrics
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Cytokine treated normal human epidermal keratinocytes
Normal human epidermal keratinocytes (NHEK) from neonatal foreskin were cultured in serum-free EpiLife medium with human KC growth supplement (0.2% bovine pituitary extract (v/v), 5ug bovine insulin, 5ug/ml bovine transferrin, 0.5ng/ml human EGF, and 0.18 ug/ml hydrocortisone) from Cascade Biologics. Cultures were treated with recombinant cytokines from R&D Systems. J Immunol. 2007 Feb 15;178(4):2229-40.
Keywords: cytokine response expression profiling by array
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