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Examples: APPROACH

361 projects found

Blockade of interferon-γ normalizes IFN regulated ge...

Normal donor blood was incubated with or without IFN-g stimulation to establish an IFN-g gene signature. Systemic lupus erythematosus subjects were treated with placebo or AMG 811, a therapeutic anti-IFN--g antibody, and changes in the IFN--g signature in whole blood of these subjects was measured.

Keywords: NCBI GEO expression profiling by array

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Bruton's Tyrosine Kinase Regulates TLR9 but not TLR7...

Plasmacytoid dendritic cells (pDCs) can be activated by the endosomal TLRs, and contribute to the pathogenesis of systemic lupus erythematosus (SLE) by producing type I IFNs. Thus, blocking TLR-mediated pDC activation may represent a useful approach for the treatment of SLE. In an attempt to identify a therapeutic target for blocking TLR signaling in pDCs, we investigated the contribution of Bruton's tyrosine kinase (Btk) to the activation of pDCs by TLR7 and TLR9 stimulation by using a selec...

Keywords: NCBI GEO expression profiling by array

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CANCER-ID

Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids in blood

Keywords: IMI projects Cancer Tools for predicting/monitoring efficacy

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CARDIATEAM

Cardiomyopathy in type 2 diabetes mellitus

Keywords: IMI projects Cardiovascular diseases Diabetes & metabolic disorders Biobanks Disease taxonomy

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CARE

Corona accelerated R&D in Europe

Keywords: IMI projects Respiratory diseases Infectious diseases Coronaviruses Conducting clinical trials Target identification Drug discovery Drug repurposing

fairplus stamp

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CHEM21

Chemical manufacturing methods for the 21st century pharmaceutical industries

Keywords: IMI projects Environmental aspects Manufacturing technologies

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COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

Keywords: IMI projects Antimicrobial resistance Infectious diseases ND4BB Clinical trial design Conducting clinical trials

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COMBACTE-CDI

Combatting Bacterial Resistance in Europe - Clostridium Difficile Infections

Keywords: IMI projects Antimicrobial resistance Infectious diseases ND4BB Clinical trial design Clinical networks Real-world data, evidence

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