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375 projects found

ZNF750 in late keratinocyte differentiation

Disrupted skin barrier due to altered keratinocyte differentiation is common in pathologic conditions such as atopic dermatitis, ichthyosis and psoriasis. However, the molecular cascades governing keratinocyte terminal differentiation are still poorly understood. We have previously demonstrated that a dominant mutation in ZNF750 leads to a clinical phenotype that reminiscent of psoriasis and seborrheic dermatitis. We defined ZNF750 as a nuclear effector that is strongly activated in and essen...

Keywords: NCBI GEO expression profiling by array

361

asthma

Bronchial Epithelial Cells were isolated processed as described (Chu et al., 2002 and Zhao et al., 2011). The objective of the study was to identify differentially expressed genes between normal control (NC), mild-moderate asthmatic (MMA) and severe asthmatic (SA) patients.

Keywords: NCBI GEO expression profiling by array

362

c4c

conect4children - Collaborative network for European clinical trials for children

Keywords: IMI projects Clinical trial design Clinical networks Patient involvement in R&D Tools for pediatrics

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363

chronic temporal lobe epilepsy: biopsy hippocampus

Analysis of biopsy hippocampal tissue of patients with pharmacoresistant temporal lobe epilepsy (TLE) undergoing neurosurgical removal of the epileptogenic focus for seizure control. Chronic TLE goes along with focal hyperexcitability. Results provide insight into molecular mechanisms that may play a role in seizure propensity

Keywords: NCBI GEO expression profiling by array

364

eTOX

Integrating bioinformatics and chemoinformatics approaches for the development of Expert systems allowing the in silico prediction of toxicities

Keywords: IMI projects Tools for predicting/monitoring efficacy 3Rs - animal use in research

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365

eTRANSAFE

Enhacing TRANslational SAFEty Assessment through Integrative Knowledge Management

Keywords: IMI projects Tools for predicting/monitoring safety Big data and knowledge management 3Rs - animal use in research

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366

eTRIKS

Delivering European Translational Information & Knowledge Management Services

Keywords: IMI projects Big data and knowledge management

367

expression profiling of responsiveness to infliximab...

Identifying gene expression profiles as predictors of a good vs poor response to a combined infliximab/methotrexate treatment in rheumatoid arthritis patients.

Keywords: drug response expression profiling by array

368