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376 projects found

Whole transcriptome analysis of the hippocampus: tow...

Purpose: to evaluate changes in the transcriptome of hippocampal cells during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures.Experimental Design: Gene expression profiling was analyzed in hippocampi of rats subjected to the pilocarpine model of epilepsy at different times during the course of epileptogenesis: 3 days post-SE (3D), 7 days post-SE (7D), and immediately (up to 12h) after the first spontaneous seizur...

Keywords: gene expression changes during epileptogenesis. expression profiling by array



Zoonotic anticipation and preparedness initiative

Keywords: IMI projects Infectious diseases Vaccines


ZNF750 in late keratinocyte differentiation

Disrupted skin barrier due to altered keratinocyte differentiation is common in pathologic conditions such as atopic dermatitis, ichthyosis and psoriasis. However, the molecular cascades governing keratinocyte terminal differentiation are still poorly understood. We have previously demonstrated that a dominant mutation in ZNF750 leads to a clinical phenotype that reminiscent of psoriasis and seborrheic dermatitis. We defined ZNF750 as a nuclear effector that is strongly activated in and essen...

Keywords: NCBI GEO expression profiling by array



Bronchial Epithelial Cells were isolated processed as described (Chu et al., 2002 and Zhao et al., 2011). The objective of the study was to identify differentially expressed genes between normal control (NC), mild-moderate asthmatic (MMA) and severe asthmatic (SA) patients.

Keywords: NCBI GEO expression profiling by array



conect4children - Collaborative network for European clinical trials for children

Keywords: IMI projects Clinical trial design Clinical networks Patient involvement in R&D Tools for pediatrics

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chronic temporal lobe epilepsy: biopsy hippocampus

Analysis of biopsy hippocampal tissue of patients with pharmacoresistant temporal lobe epilepsy (TLE) undergoing neurosurgical removal of the epileptogenic focus for seizure control. Chronic TLE goes along with focal hyperexcitability. Results provide insight into molecular mechanisms that may play a role in seizure propensity

Keywords: NCBI GEO expression profiling by array



Integrating bioinformatics and chemoinformatics approaches for the development of Expert systems allowing the in silico prediction of toxicities

Keywords: IMI projects Tools for predicting/monitoring efficacy 3Rs - animal use in research

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Enhacing TRANslational SAFEty Assessment through Integrative Knowledge Management

Keywords: IMI projects Tools for predicting/monitoring safety Big data and knowledge management 3Rs - animal use in research

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