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Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies

Keywords: IMI projects Autoimmune diseases Cancer 3Rs - animal use in research


isolated alveolar macrophages

This series represents isolated alveolar macrophages from human subjects.

Keywords: parallel sample expression profiling by array


whole brains from nicotinic acetylcholine receptor s...

Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-containing nAChRs activity, we compared the mRNA expression profiles of brains from beta4-/- and wild-type mice using Affymetrix U74Avr2 microarray.

Keywords: knockout mice nicotinic acetylcholine receptor expression profiling by array