Data Catalog

Type I Interferon: Potential Therapeutic Target for ...

We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. Concordant overexpression of IFN-c and TNF-a–inducible gene signatures occ...

Keywords: Affymetrix Human Genome U133 Plus 2.0 array expression profiling by array

345

Project website

U-BIOPRED

Unbiased BIOmarkers in PREDiction of respiratory disease outcomes

Keywords: IMI projects Respiratory diseases Disease taxonomy

346

Start: 2009-10-01
Project website

ULTRA-DD

Unrestricted leveraging of targets for research advancement and drug discovery

Keywords: IMI projects Autoimmune diseases Drug discovery

347

Start: 2015-03-01
Project website

UNITE4TB

Academia and industry united innovation and treatment for tuberculosis

Keywords: IMI projects Antimicrobial resistance Infectious diseases AMR Accelerator Clinical trial design Conducting clinical trials

348

Start: 2021-06-01
Project website

Upper airway gene expression is an effective surroga...

Molecular profiling studies in asthma cohorts have identified a Th2-driven asthma subtype, characterized by elevated lower airway expression of POSTN, CLCA1 and SERPINB2. To assess upper airway gene expression as a potential biomarker for lower airway Th2 inflammation, we assayed upper airway (nasal) and lower airway (bronchial) epithelial gene expression, serum total IgE, blood eosinophils and serum periostin in a cohort of 54 allergic asthmatics and 30 matched healthy controls. 23 of 51 ast...

Keywords: NCBI GEO expression profiling by array

349