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375 projects found
Time course of bone marrow-derived macrophages simul...
The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-κB, C/EBPδ, and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally v...
Keywords: NCBI GEO macrophages expression profiling by array
329
Time-dependent transcriptomic profiles of mouse hipp...
Mesial Temporal Lobe Epilepsy (MTLE) is a chronic disease characterized by recurrent unprovoked partial seizures. Current treatments lack long-term efficacy and typically act only to ameliorate the symptomology, rather than to modify the course of the disease. Chronic kainic acid (KA)-induced models of MTLE mimic prominent histopathological and electroencephalographic features of human MTLE, including hippocampal sclerosis, CA1 neuronal loss, astrogliosis, microgliosis, and electrographic hip...
Keywords: NCBI GEO expression profiling by array
330
To identify gene markers which differentiate between...
Aspirin-exacerbated respiratory disease (AERD) has association with severe asthma and aspirin can cause asthma to worsen, often in the form of a severe and sudden attack. The oral aspirin challenge (OAC) is the gold standard to confirm the diagnosis of AERD but it is time consuming and produces serious complications in some cases. Therefore more efficient and practical method is needed to predict AERD patients. The aim of the present study was to identify AERD-related gene expression in perip...
Keywords: NCBI GEO expression profiling by array
331
TransBioLine
Translational Safety Biomarker Pipeline (TransBioLine): Enabling development and implementation of novel safety biomarkers in clinical trials and diagnosis of disease
Keywords: IMI projects Tools for predicting/monitoring safety
332
TransQST
Translational quantitative systems toxicology to improve the understanding of the safety of medicines
Keywords: IMI projects Tools for predicting/monitoring efficacy
333
Transcriptional Response of Human Microglial Cells t...
Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed a series of experiments to acertain the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. Primary human microglial cells were either untreated o...
Keywords: time-course microglia interferon-gamma macrophages expression profiling by array
334
Transcriptional analysis of left-sided colitis, panc...
This study characterizes the inflammatory processes in left-sided colitis, pancolitis, and UC-associated dysplasia at the transcriptional level in colonics biopsies in order to identify potential biomarkers and transcripts of importance for the carcinogenic behaviour of chronic inflammation
Keywords: NCBI GEO expression profiling by array
335
Transcriptional analysis of multiple brain regions i...
Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms.This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
336
