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375 projects found
Systematic meta-analysis and replication of genome-w...
Analysis of substantia nigra from postmortem brains of 4 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.
Keywords: NCBI GEO expression profiling by array
313
Systemic lupus erythematosus
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
314
Systems-based analyses of brain regions functionally...
Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum and cortex are functionally connected with increasing degreesof alpha-synuclein pathology in Parkinson's disease. Functional and causal pathway analysis of gene expression and proteomic alterations in these three regions revealed pathways that correlated with depositionof alpha-synuclein. Microarray and RNAseq experiments revealed previously unidenti...
Keywords: NCBI GEO expression profiling by array
315
T helper lymphocyte- and monocyte-specific type I in...
This study demonstrates quantitative and qualitative differences between type I IFN signatures in autoimmunity and viral infection using purified CD4pos T cells and CD16pos- and CD16neg-monocyte subsets. We were able to discriminate between cell-specific viral response signatures and the pathogenically amplified IFN signatures observed in autoimmunity. The differences were of both a qualitative and quantitative nature, as the signatures in the patients with SLE were characterized by much more...
Keywords: NCBI GEO expression profiling by array
316
T2EVOLVE
Accelerating development and improving access to CAR and TCR-engineered T cell therapy
Keywords: IMI projects Cancer Biologicals Tools for predicting/monitoring efficacy Tools for predicting/monitoring safety Manufacturing technologies
317
TRANSLOCATION
Molecular basis of the bacterial cell wall permeability
Keywords: IMI projects Antimicrobial resistance Infectious diseases ND4BB Drug discovery
318
TREM-1 is a novel therapeutic target in Psoriasis
Our group recently described a population of antigen presenting cells that appear to be critical in psoriasis pathogenesis, termed inflammatory myeloid dendritic cells (CD11c+ BDCA1-). Triggering receptor expressed on myeloid cells type-1 (TREM-1) signaling was a major canonical pathway in the published transcriptome of these cells. TREM-1 is a member of the immunoglobulin superfamily, active through the DAP12 signaling pathway, with an unknown ligand. Activation through TREM-1 induces inflam...
Keywords: NCBI GEO expression profiling by array
319
TRIC-TB
Boosting Ethionamide efficacy and lowering the dose with a small molecule transcriptional modulators, to overcoming MDR-TB infections and define a new place for Ethionamide in 1st-line TB treatments
Keywords: IMI projects Antimicrobial resistance Infectious diseases AMR Accelerator Conducting clinical trials
320