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375 projects found
RealHOPE
Real world handling of protein drugs - exploration, evaluation and education
Keywords: IMI projects Biologicals Tools for predicting/monitoring safety Manufacturing technologies
289
Repeated observation of breast tumor subtypes in ind...
Abstract: Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant subgroups. In this study, we have refined the previously defined subtypes of breast tumors that could be distinguished by their distinct patterns of gene expression. A total of 115 malignant breast tumors were analyzed by hierarchical clustering based on patterns of expression of 534 "intrinsic" genes and shown to subdivide into one basal-like, one ERBB2-...
Keywords: NCBI GEO expression profiling by array
290
RespiriNTM
Progress novel assets (one FIH start) for non-tubercular mycobacteria that may act synergistically with bedaquiline and cytochrome bc drugs
Keywords: IMI projects Antimicrobial resistance Infectious diseases AMR Accelerator Conducting clinical trials Target identification
291
RespiriTB
Progress new assets (one pre-new molecular entity and one first-time-in-human start) for tuberculosis that act synergistically with bedaquiline, cytochrome bc or cytochrome bd inhibitors
Keywords: IMI projects Antimicrobial resistance Infectious diseases AMR Accelerator Conducting clinical trials
292
Restoration of regulatory and effector T cell balanc...
Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably the expansion of Tregs and the decrease of Th1 and Th17 cells. A significant correlation between higher disease activity and lower serum 25-hydroxyvitamin D levels was also shown.This preliminary s...
Keywords: NCBI GEO expression profiling by array
293
Reversal of Atopic Dermatitis with Narrow-Band UVB P...
Background: Atopic dermatitis (AD) is a common inflammatory skin disease exhibiting a predominantly Th2/“T22” immune activation and a defective epidermal barrier. Narrow-band UVB (NB-UVB) is considered an efficient treatment for moderate to severe AD. In psoriasis, NB-UVB has been found to suppress the Th1/Th17 immune polarization with subsequent reversal of epidermal hyperplasia. The immunomodulatory effects of this treatment are largely unknown in AD. Our study evaluates the effects of NB-U...
Keywords: NCBI GEO expression profiling by array
294
Rheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from the Stanford Functional Genomics Facility (http://microarray.org/sfgf/) printed on aminosilane-coated slides containing ~20.000 unique genes. Only one batch of arrays was used for all experiments. Fi...
Keywords: NCBI GEO expression profiling by array
295
SAFE-T
Safer and Faster Evidence-based Translation
Keywords: IMI projects Tools for predicting/monitoring efficacy
296
