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INNODIA

Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes.

Keywords: IMI projects Diabetes & metabolic disorders Clinical trial design Disease taxonomy

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INNODIA HARVEST

Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA

Keywords: IMI projects Diabetes & metabolic disorders Clinical trial design Conducting clinical trials Disease taxonomy

194

ITCC-P4

ITCC pediatric preclinical POC platform

Keywords: IMI projects Cancer Tools for predicting/monitoring safety Tools for pediatrics

195

Identification and characterization of small molecul...

An essential function of the human epidermis is the maintenance of a protective barrier against the environment. As a consequence, keratinocytes, which make up this layer of the skin, undergo an elaborate process of self-renewal, terminal differentiation and cell death. Misregulation of these processes can lead to several human diseases including psoriasis and basal cell and squamous cell carcinomas. To identify novel regulators of keratinocyte differentiation, a cell-based screen of small mo...

Keywords: time course of compound treatment expression profiling by array

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Identification of markers of responsiveness in rheum...

Despite the increasing of available drugs in RA, the overall rate of non response is 30 to 40% of treated patients. To optimize the drug prescription and better elaborate the therapeutic strategies, gene profiling in PBMCs was used to predict the responsiveness to anakinra. Thirty two patients treated by anakinra (100mg/day s.c.) and méthotrexate, were categorized as responders whenever a change of Disease Activity Score 28 > 1.2 was obtained at 3 months. Blood from treated patients was colle...

Keywords: anakinra effect expression profiling by array

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ImmGen Microarray Phase 1

Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. Data is released monthly in batches of cell populations.

Keywords: NCBI GEO macrophages expression profiling by array

198

ImmUniverse

Immuniverse research projects at LCSB aim at to better control and treatment of immune-mediated diseases by exploring the universe of microenvironment-imposed tissue signatures and their correlates in liquid biopsies. The precise aims of the ImmUniverse project are given below: Objective 1. Comprehensive molecular characterization of intestinal/dermal microenvironment and immune cell profiles that provides a data foundation for advanced bioinformatics, statistical and model-based analysis. ...

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Immune safety avatar: nonclinical mimicking of the i...

Certain treatments for cancers and autoimmune diseases work by altering the immune system. However, a major challenge for researchers is identifying potential efficacy and safety issues with these treatments early in drug development, before they are tested in humans. Part of the problem is that the tests used early in drug development do not reflect the full complexity of the human immune system. In addition, these tests tend to be based on a healthy immune system, which is different to the ...

Keywords: IMI projects Immunology Autoimmune diseases Tools for predicting/monitoring efficacy Tools for predicting/monitoring safety

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