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375 projects found
IFNalpha kinoid induces neutralizing anti-IFNalpha a...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
185
IL-1 treatment of human epidermal keratinocytes
Interleukin-1 is a proinflammatory and immunomodulatory cytokine that plays a crucial role in inflammatory diseases of the skin, including bacterial infections, bullous diseases, UV damage and especially psoriasis. To characterize the molecular effects of IL-1 in epidermis, we defined the transcriptional changes in human epidermal keratinocytes 1, 4, 24, and 48 h after treatment with IL-1a. IL-1 significantly regulated 388 genes, including genes associated with proteolysis, adhesion, signal t...
Keywords: Time course expression profiling by array
186
IL-17A is an essential cytokine to sustain pathogeni...
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies in model systems indicate that IL-22 has a dominant pathogenic role, there is evolving evidence that IL-17 contributes to features of psoriasis. To more fully understand the role of IL-17 in human ...
Keywords: NCBI GEO expression profiling by array
187
IM2PACT
Investigating mechanisms and models predictive of accessibility of therapeutics (IM2PACT) into the brain
Keywords: IMI projects Diabetes & metabolic disorders Neurodegenerative diseases Alzheimer's disease Tools for predicting/monitoring efficacy Drug delivery
188
IMI-PainCare
Improving the care of patients suffering from acute or chronic pain
Keywords: IMI projects Neurodegenerative diseases Pain Tools for predicting/monitoring efficacy Patient involvement in R&D Disease taxonomy Imaging
189
IMIDIA
Innovative Medicines Initiative for Diabetes
Keywords: IMI projects translational medicine diabetes metabolic disorders Tools for predicting/monitoring safety
190
IMMUCAN
Integrated immunoprofiling of large adaptive cancer patients cohorts
Keywords: IMI projects Cancer Biologicals Tools for predicting/monitoring efficacy Tools for predicting/monitoring safety
191
IMPRiND
Inhibiting misfolded protein propagation in neurodegenerative diseases
Keywords: IMI projects Neurodegenerative diseases Alzheimer's disease Stem cells Target identification Drug discovery
192
