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375 projects found
Human colon expression in healthy, CD, treated CD, and UC
Activation of inflammatory pathways in human IBDIL-6:STAT3 pathways are activated in the affected colon in IBD. However, the functional implications of this are not known. We hypothesized that pro-inflammatory IL-6:STAT3 dependent networks would be up regulated in the colon of pediatric patients with Crohn Disease (CD) and Ulcerative Colitis (UC), and that these would regulate leukocyte survival, proliferation, and recruitment to the gut. These experiments tested differential colon gene ex...
Keywords: Single time point in CD UC and healthy controls. expression profiling by array
177
Human immune cell transcriptome
In the present study we used Affymetrix oligonucleotide microarrays to produce gene transcription profiles for the major leukocyte types in humans. This comprehensive dataset enabled us to not only establish which genes were expressed in each leukocyte type, but also which genes were expressed in each subset after activation. The used of a comprehensive dataset of gene profiles from all the major human leukocyte subsets enabled a novel and powerful means for identification of genes associated...
Keywords: Cell type comparison macrophages expression profiling by array
178
Human keratinocytes have a response to injury that u...
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive immune responses, e.g. CCL20, in their early state of activation without signals from infiltrating T cells. This study aims to isolate the immediate alterations in protective and inflammatory gene ...
Keywords: NCBI GEO expression profiling by array
179
Human keratinocytes stimulated with IL-17C
IL-17C is important for the pathogenesis of inflammatory diseases such as IBD and psoriasis. We found that IL-17C is highly induced in a murine model of psoriasis. Recent results suggest that IL-17C can target epithelial cells that express both IL-17RA and IL-17RE receptor chains.Here we identify genes induced in response to IL-17C treatment of human keratinocytes to provide the tools for dissection of the IL-17C signaling pathway.
Keywords: NCBI GEO expression profiling by array
180
Human peripheral blood cells: systemic lupus erythem...
Gene expression profiling of peripheral blood cells from patients with systemic lupus erythematosus (SLE) vs healthy individual (HI).
Keywords: NCBI GEO expression profiling by array
181
Human rhinovirus infection causes different DNA meth...
Background: Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. Objective: To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA methylation profiling in asthmatic and healthy nasal epithelial cells (NECs) during Human Rhinovirus (HRV) infection in vitro. Methods: Global and loci-specific methylation profiles were determined via Alu element and Infinium Human Methylation 450K microarray respect...
Keywords: NCBI GEO methylation profiling by genome tiling array
182
Hypo-RESOLVE
Hypoglycaemia - REdefining SOLutions for better liVEs
Keywords: IMI projects Diabetes & metabolic disorders Disease taxonomy
183
IDEA-FAST
Identifying digital endpoints to assess fatigue, sleep and activities in daily living in neurodegenerative disorders and immune-mediated inflammatory diseases
Keywords: IMI projects Neurodegenerative diseases Autoimmune diseases Clinical trial design Digital health Real-world data, evidence
184
