Data Catalog

Gene expression profiles in synovial biopsies from p...

Rheumatoid arthritis (RA) is an inflammatory joint disorder that results in progressive joint damage when insufficiently treated. In order to prevent joint destruction and functional disability in RA, early diagnosis and initiation of appropriate treatment with Disease-Modifying Antirheumatic Drugs (DMARDs) is needed. However, in daily clinical practice, patients may initially display symptoms of arthritis that do not fulfil the classification criteria for a definite diagnosis of RA, or any o...

Keywords: NCBI GEO expression profiling by array

153

Project website

Gene expression profiling and correlation with outco...

The aims of this study were to assess the feasibility of prospective pharmacogenomics research in multicenter international clinical trials of bortezomib in multiple myeloma and to develop predictive classifiers of response and survival with bortezomib. Patients with relapsed myeloma enrolled in phase 2 and phase 3 clinical trials of bortezomib and consented to genomic analyses of pretreatment tumor samples. Bone marrow aspirates were subject to a negative-selection procedure to enrich for tu...

Keywords: Gene expression profiling correlation with outcome in clinical trials of the proteasome inhibitor bortezomib expression profiling by array

154

Project website

Gene expression profiling in psoriatic lesional and ...

To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. Furthermore, we explored the effects of various doses of brodalumab on lesional skin over time.

Keywords: NCBI GEO expression profiling by array

155

Project website

Gene expression profiling of human monocytes and mon...

In this study we analyzed the gene expression profiles of human monocytes and monocyte-dervied-macrophages.

Keywords: Gene expression profiling macrophages expression profiling by array

156

Project website

Gene expression profiling of parkinsonian substantia nigra

Affymetrix HG-Focus array was used to determine a global gene expression profile of clinically and neuropathologically confirmed cases of sporadic Parkinson's disease compared to controls.Major alterations were detected in signal transduction, protein degradation, dopaminergic transmission/metabolism, energy pathways/glycolysis, cell adhesion/cytoskeleton, extracellular matrix components and cell cycle functional classes.

Keywords: NCBI GEO expression profiling by array

157

Project website

Genome-Wide Profiling of Airway Epithelial Cells in ...

We collected airway epithelial brushings for microarray analysis from 42 asthmatics and two control groups – 28 healthy subjects and 16 smokers. A subgroup of 32 asthmatics completed a randomized placebo-controlled trial of fluticasone propionate in which collection of brushings was repeated after 1 week of treatment.

Keywords: disease state analysis clinical trial expression profiling by array

158

Project website

Genome-wide analysis of Crohn's disease and ulcerati...

Gene expression patterns of Crohn's disease (CD) and ulcerative colitis (UC) colonic specimens were analyzed using whole-genome microarrays. Healthy control samples were included in order to detect gene expression changes associated with CD or UC. CD and UC samples were also compared in order to identify the molecular mechanisms that distinguish both fenotypes of inflammatory bowel disease.

Keywords: NCBI GEO expression profiling by array

159