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375 projects found
Gene Expression Analysis in Peripheral Blood of Pati...
Peripheral blood cells in patients with rheumatoid arthritis before/after IL-6 inhibitionThe obtained conclusions on the change of each gene expression level before and after MRA medication were as follows.(1) In the case of IL-6, the specific time profile that the expression level dropped at day 21 and increased to some extent at day 42 was observed in 2 of 18 subjects. In other subjects, quite small change or small increase after day 7 was observed.(2) In the case of IL-6R as well as in IL-...
Keywords: NCBI GEO expression profiling by array
137
Gene Expression Profiles in a Rabbit Model of System...
We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model of Systemic Lupus Erythematosus (SLE) in which peptide immunization led to lupus-like autoantibody production including anti-Sm, -RNP, -SS-A, -SS-B and -dsDNA. Some neurological symptoms in form of seizures and nystagmus were observed. The animals used in the previous and in the present study were from a National Institute of Allergy and Infectious Diseases colony of rabbits that were pedigreed, immunoglobulin...
Keywords: NCBI GEO expression profiling by array
138
Gene Expression Profiles of RAW264.7 Macrophages Sti...
Background: Toll-like family of receptors recognizes pathogen-associated molecular patterns (PAMPs) from different organisms. TLR4 is the receptor for bacterial lipopolysaccharide (LPS), dsRNA viral mimic poly(I:C) binds to TLR3, and bacterial CpG DNA signals through TLR9. TLR4 signaling is mediated by adaptor molecules Myd88 and TRIF while TLR3 pathway involves only the TRIF adaptor and TLR9 signals solely through Myd88. Methods: To identify genes other than those in TLR pathways th...
Keywords: time course macrophages expression profiling by array
139
Gene Expression Profiling of Rat Hippocampus Followi...
Soman (O-Pinacolyl methylphosphonofluoridate) is a potent neurotoxicant. Acute exposure to soman causes profound inhibition of the critical enzyme acetylcholinesterase, resulting in excessive levels of the neurotransmitter acetylcholine. Excessive acetylcholine levels cause convulsions, seizures, and respiratory distress. The initial cholinergic crisis can be overcome by rapid anti-cholinergic therapeutic intervention, resulting in increased survival. However, conventional treatments do n...
Keywords: Time-course toxicant exposure expression profiling by array
140
Gene coexpression network and community detection an...
Prolonged febrile seizures history (FH) in early childhood is associated with refractory temporal lobe epilepsy (RTLE). FH-RTLE patients may have early (E, before 4 YOA) or late (L, mid-adolescence, early adult life) disease onset. In order to investigate molecular mechanisms underlying E and L forms we compared differentially expressed (DE) and complete (CO) transcriptional networks from hippocampal CA3 explants obtained from E and L patients.
Keywords: NCBI GEO expression profiling by array
141
Gene expression alterations in the cerebellum and gr...
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized the cystatin B deficient mice (Cstb-/-), a model for the disease. We have characterized the gene expression changes from the cerebellum of Cstb-/- mouse at postnatal day 7 (P7) and P30 as well as i...
Keywords: NCBI GEO expression profiling by array
142
Gene expression analysis in absence epilepsy using a...
Objective:To identify genes involved in idiopathic absence epilepsies by analysing gene expression using a monozygotic (MZ) twin design.Methods:Genome-wide gene expression in lymphoblastoid cell lines was determined using microarrays derived from five discordant and four concordant MZ twin pairs with idiopathic absence epilepsies and five unaffected MZ twin pairs. Gene expression was analysed using three strategies: discordant MZ twins were compared as matched pairs, MZ twins concordant for ...
Keywords: Childhood Absence Epilepsy Juvenile Absence Epilepsy Idiopathic Generalised Epilepsy gene expression twin study monozygotic twins expression profiling by array
143
Gene expression analysis in children with complex se...
The differences of clinical characteristics in complex seizures induced by influenza A(H1N1)pdm09 and rotavirus gastroenteritis are well known, but the pathogenic mechanisms remain unclear. We analyzed the gene expression profiles in the peripheral whole blood cells isolated from pediatric patients using an Affymetrix oligonucleotide microarray.Results provide insights into the difference of the pathogenesis in the patients with complex seizures induced by influenza A(H1N1)pdm09 and rotavirus...
Keywords: NCBI GEO expression profiling by array
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