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375 projects found
Down-regulation of Interferon signature in systemic ...
We performed a phase I/II, randomized, double-blind, placebo-controlled dose-escalation study to examine the safety, immunogenicity, and biological effects of active immunization with interferon alpha-Kinoid (IFN-K) in systemic lupus erythematosus (SLE) patients. Women 18-50 years of age with mild to moderate SLE were immunized with three (n=10) or four doses (n=9) of 30, 60, 120, 240 microgram IFN-K or saline.Anti-IFNalpha antibodies were detected in all IFN-K-immunized patients. Transcripto...
Keywords: NCBI GEO expression profiling by array
73
Down-regulation of Interferon signature in systemic ...
Interferon-alpha Kinoid (IFN-K) is a therapeutic vaccine composed of IFN-alpha2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients (see GSE39088). Here, we analyzed extended follow-up data from IFN-K-treated patients, in terms of persistence of neutralizing anti-IFN± Abs, gene expression profiling and safety.Follow-up analyses in six patients confirmed a sig...
Keywords: NCBI GEO expression profiling by array
74
EBODAC
Communication strategy and tools for optimizing the impact of Ebola vaccination deployment
Keywords: IMI projects Infectious diseases Ebola and related diseases Vaccines Ebola+ Tools for predicting/monitoring efficacy
75
EBOMAN
Manufacturing and development for rapid access Ebola vaccine
Keywords: IMI projects Infectious diseases Ebola and related diseases Vaccines Ebola+ Manufacturing technologies
76
EBOVAC1
Development of a prophylactic Ebola vaccine using an heterologous prime-boost regimen
Keywords: IMI projects Infectious diseases Ebola and related diseases Vaccines Ebola+ Clinical trial design Conducting clinical trials
77
EBOVAC2
Development of a prophylactic Ebola vaccine using an heterologous prime-boost regimen: phase II
Keywords: IMI projects Infectious diseases Ebola and related diseases Vaccines Ebola+ Conducting clinical trials
78
EBOVAC3
Bringing a prophylactic Ebola vaccine to licensure
Keywords: IMI projects Infectious diseases Ebola and related diseases Vaccines Ebola+ Conducting clinical trials
79
EBiSC
EBiSC - European Bank for induced pluripotent Stem Cells
Keywords: IMI projects Cardiovascular diseases Diabetes & metabolic disorders Cancer Alzheimer's disease Biobanks Stem cells
80
