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376 projects found


Identification of the molecular mechanisms of non-response to treatments, relapses and remission in autoimmune, inflammatory, and allergic conditions

Keywords: IMI projects Respiratory diseases Autoimmune diseases Tools for predicting/monitoring efficacy Biobanks Disease taxonomy


A Whole Blood Molecular Signature for the Identifica...

Despite the significant reduction in the overall burden of cardiovascular disease (CVD) over the past decade, CVD still accounts for a third of all deaths in the United States and worldwide each year. While efforts to identify and reduce risk factors for atherosclerotic heart disease (i.e. hypertension, dyslipidemia, diabetes mellitus, cigarette smoking, inactivity) remain the focus of primary prevention, the inability to accurately and temporally predict acute myocardial infarction (AMI) imp...

Keywords: NCBI GEO expression profiling by array


A global transcriptome analysis of keratinocytes upo...

MiR-31 is one of the most highly overexpressed miRNAs in psoriasis skin; however, its biological role in the disease has not been studied. Here we show that miR-31 is markedly overexpressed in psoriasis keratinocytes. To study the biological role of miR-31 in keratinocytes, we transfected miR-31 hairpin inhibitor (anti-miR-31) into primary human keratinocytes to inhibit endogenous miR-31. We performed a global transcriptome analysis of keratinocytes upon suppression of endogenous miR-31 using...

Keywords: NCBI GEO expression profiling by array


A modular analysis framework for the discovery of bi...

Transcriptional modules were used as a basis for the selection of biomarkers and the development of a multivariate transcriptional indicator of disease progression in patients with systemic lupus erythematosus.

Keywords: NCBI GEO expression profiling by array


A single intradermal injection of IFN-γ induces a ps...

psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-γ is involved in many cellular processes, including activation of T cells and dendritic cells (DCs), antigen processing and presentation, cell adhesion and trafficking, and cytokine and chemokine production, IFN-γ-producing Th1 cells were proposed to be integral to the pathogenesis of psoriasis. Recently, IFN-γ was shown to enhance IL-23 and IL-1 production by DCs and subsequently induce Th17 cells, import...

Keywords: NCBI GEO expression profiling by array


A sputum gene expression signature of six biomarkers...

This study identifies differentially expression genes in the sputum of people with eosinophilic, neutrophilic and paucigranulocytic asthma. A selection of markers identified using this microarray were further validated using qPCR on a wider sample set.

Keywords: NCBI GEO expression profiling by array



Antibiotic distribution and recovery in tissue

Keywords: IMI projects Antimicrobial resistance Infectious diseases AMR Accelerator Conducting clinical trials



Anti-Biopharmaceutical Immunization: Prediction and Analysis of Clinical Relevance to Minimize the Risk

Keywords: IMI projects Translational Medicine Biologicals Tools for predicting/monitoring efficacy Manufacturing technologies

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