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Monocytes of patients with familial hypercholesterol...

Background: Elevated plasma cholesterol promotes the formation of atherosclerotic lesions in which monocyte-derived lipid-laden macrophages are frequently found. To analyze, if circulating monocytes already show increased lipid content and differences in lipoprotein metabolism, we compared monocytes from patients with Familial Hypercholesterolemia (FH) with those from healthy individuals.Methods: Cholesterol and oxidized cholesterol metabolite serum levels of FH and of healthy, gender/age mat...

Keywords: Micro-array analysis cell type comparison, macrophages expression profiling by array

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