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177 projects found
Gene coexpression network and community detection an...
Prolonged febrile seizures history (FH) in early childhood is associated with refractory temporal lobe epilepsy (RTLE). FH-RTLE patients may have early (E, before 4 YOA) or late (L, mid-adolescence, early adult life) disease onset. In order to investigate molecular mechanisms underlying E and L forms we compared differentially expressed (DE) and complete (CO) transcriptional networks from hippocampal CA3 explants obtained from E and L patients.
Keywords: NCBI GEO expression profiling by array
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Gene expression alterations in the cerebellum and gr...
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized the cystatin B deficient mice (Cstb-/-), a model for the disease. We have characterized the gene expression changes from the cerebellum of Cstb-/- mouse at postnatal day 7 (P7) and P30 as well as i...
Keywords: NCBI GEO expression profiling by array
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Gene expression analysis in absence epilepsy using a...
Objective:To identify genes involved in idiopathic absence epilepsies by analysing gene expression using a monozygotic (MZ) twin design.Methods:Genome-wide gene expression in lymphoblastoid cell lines was determined using microarrays derived from five discordant and four concordant MZ twin pairs with idiopathic absence epilepsies and five unaffected MZ twin pairs. Gene expression was analysed using three strategies: discordant MZ twins were compared as matched pairs, MZ twins concordant for ...
Keywords: Childhood Absence Epilepsy Juvenile Absence Epilepsy Idiopathic Generalised Epilepsy gene expression twin study monozygotic twins expression profiling by array
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Gene expression analysis in children with complex se...
The differences of clinical characteristics in complex seizures induced by influenza A(H1N1)pdm09 and rotavirus gastroenteritis are well known, but the pathogenic mechanisms remain unclear. We analyzed the gene expression profiles in the peripheral whole blood cells isolated from pediatric patients using an Affymetrix oligonucleotide microarray.Results provide insights into the difference of the pathogenesis in the patients with complex seizures induced by influenza A(H1N1)pdm09 and rotavirus...
Keywords: NCBI GEO expression profiling by array
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Gene expression analysis of TSC-tubers reveals incre...
Cortical tubers in patients with tuberous sclerosis complex (TSC) are associated with cognitive disability and intractable epilepsy. While these developmental malformations are believed to result from the effects of TSC1 or TSC2 Gene mutations, the molecular mechanisms leading to tuber formation during brain development as well as the onset of seizures remain largely unknown. We used the Affymetrix Gene Chip platform as a genome-wide strategy to define the Gene expression profile of cortical ...
Keywords: NCBI GEO expression profiling by array
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Gene expression analysis of macrophages from ankylos...
OBJECTIVE: To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern. METHODS: Macrophages were derived from the peripheral blood of 8 AS patients (median disease duration 13 years [range <1-43 years]) and 9 healthy control subjects over 7 days with the use of granulocyte-macrophage colony-stimulating factor. Cells were stimulated for 24 hours with interferon-gamma (IFNgamma; 100 units/ml), ...
Keywords: Disease state analysis with treatment effect macrophages expression profiling by array
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Gene expression changes in blood RNA after swimming ...
Trihalomethanes (THM) are a class of disinfection by-products in chlorinated waters linked to deleterious health effects in humans although biological mechanisms are unclear. We aimed to study short-term changes in blood gene expression of adult recreational swimmers associated with physical activity and THM exposure.Adult volunteers (18-50 years, non-smokers, non-asthmatics) swam 40 minutes in an indoor chlorinated pool in Barcelona. Blood samples and THM measurements in exhaled breath were ...
Keywords: NCBI GEO expression profiling by array
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Gene expression data of skin from psoriatic patients...
Gene expression has been proposed as an intermediate phenotype that can increase power in complex trait gene-mapping studies. Psoriasis, an immune-mediated, inflammatory and hyperproliferative disease of the skin and joints, provides an ideal model system to evaluate this paradigm, as conclusive evidence demonstrates that psoriasis has a genetic basis and the disease tissue is readily accessible.To better understand the complex nature of processes in psoriasis, we characterize gene expression...
Keywords: disease state analysis expression profiling by array
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