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177 projects found
Transcriptional analysis of putamen in Parkinson's disease
Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects
Keywords: NCBI GEO expression profiling by array
161
Transcriptional analysis of whole substantia nigra i...
Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects
Keywords: NCBI GEO expression profiling by array
162
Transcriptional profiling of dentate granule cells i...
Global expression profiling of epileptogenesis has been confounded by variability across laboratories, epilepsy models, tissue sampled and experimental platforms, with the result that very few genes demonstrate consistent expression changes. The present study minimizes these confounds by combining Affymetrix microarray datasets from seven laboratories, using three status epilepticus (SE) models of epilepsy in rats (pilocarpine, kainate, self-sustained SE or SSSE) and the rat kindling model. ...
Keywords: NCBI GEO expression profiling by array
163
Transcriptional response to hypoxia of normal and rh...
Inflammatory tissues are characterized by low oxigen concentrations (hypoxia). These conditions are very different from that usually present in tissue cultures where transcriptomic profiles of human fibroblasts from inflammatory tissues have been previously analysed. The aim of this study was to characterize the changes on gene expression induced by hypoxia in human synovial fibroblasts. We used microarray expression profiling in paired normoxic and hypoxic cultures of healthy and rheumatoid ...
Keywords: NCBI GEO expression profiling by array
164
Transcriptome analysis of a chronic in vitro model o...
The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND). Many of the mechanisms of action of rotenone are posited mechanisms of neurodegeneration; however, they are not fully understood. Therefore, the study of rotenone-affected functional pathways is pertinent to the understanding of NDs pathogenesis. This report describ...
Keywords: NCBI GEO expression profiling by array
165
Transcriptome from circulating cells suggests dysreg...
Whole-genome gene expression analysis has been successfully utilized to diagnose, prognosticate, and identify potential therapeutic targets for cardiovascular disease. However, the utility of this approach to identify outcome-related genes and dysregulated pathways following first-time myocardial infarction (AMI) remains unknown and may offer a novel strategy to detect affected expressome networks that predict long-term outcome. Whole-genome microarray and targeted cytokine expression profil...
Keywords: NCBI GEO expression profiling by array
166
Type I Interferon: Potential Therapeutic Target for ...
We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. Concordant overexpression of IFN-c and TNF-a–inducible gene signatures occ...
Keywords: Affymetrix Human Genome U133 Plus 2.0 array expression profiling by array
167
Upper airway gene expression is an effective surroga...
Molecular profiling studies in asthma cohorts have identified a Th2-driven asthma subtype, characterized by elevated lower airway expression of POSTN, CLCA1 and SERPINB2. To assess upper airway gene expression as a potential biomarker for lower airway Th2 inflammation, we assayed upper airway (nasal) and lower airway (bronchial) epithelial gene expression, serum total IgE, blood eosinophils and serum periostin in a cohort of 54 allergic asthmatics and 30 matched healthy controls. 23 of 51 ast...
Keywords: NCBI GEO expression profiling by array
168
