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177 projects found
Rheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from the Stanford Functional Genomics Facility (http://microarray.org/sfgf/) printed on aminosilane-coated slides containing ~20.000 unique genes. Only one batch of arrays was used for all experiments. Fi...
Keywords: NCBI GEO expression profiling by array
137
Similarities and differences in the transcriptome of...
Phenotypic and functional diversity between macrophage subpopulations reflects their plasticity to respond to microenvironmental signals. Apart from detecting differences in expression profiles, the comparison of the transcriptomes of different macrophage populations may also allow the definition of molecular similarities between these subsets.Transcriptome analysis of human Kuppfer cells, alveolar, splenic and atherosclerotic plaque residing macrophages using microarrays, identified 42 genes...
Keywords: NCBI GEO macrophages expression profiling by array
138
Sputum gene expression profiling in asthmatics
Gene expression profiling was performed on sputum samples obtained from asthmatics and matched healthy controls, to identify markers associated with various asthma subtypes.
Keywords: NCBI GEO expression profiling by array
139
Strong Time Dependence of the 76-Gene Prognostic Signature
Background: Recently a 76-gene prognostic signature able to predict distant metastases in lymph node-negative (N-) breast cancer patients was reported. The aims of this study conducted by TRANSBIG were to independently validate these results and to compare the outcome with clinical risk assessment. Materials and Methods: Gene expression profiling of frozen samples from 198 N- systemically untreated patients was performed at the Bordet Institute, blinded to clinical data and independent of Ver...
Keywords: disease state analysis expression profiling by array
140
Systematic meta-analysis and replication of genome-w...
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.Examination of substantia nigra from postmortem brains of 8 patients with Parkinson's disease (PD).
Keywords: NCBI GEO expression profiling by array
141
Systematic meta-analysis and replication of genome-w...
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.Analysis of substantia nigrae from postmortem brains of 6 patients with Parkinson's disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.
Keywords: NCBI GEO expression profiling by array
142
Systematic meta-analysis and replication of genome-w...
Analysis of substantia nigra from postmortem brains of 4 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.
Keywords: NCBI GEO expression profiling by array
143
Systemic lupus erythematosus
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
144
