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134 projects found
Human keratinocytes stimulated with IL-17C
IL-17C is important for the pathogenesis of inflammatory diseases such as IBD and psoriasis. We found that IL-17C is highly induced in a murine model of psoriasis. Recent results suggest that IL-17C can target epithelial cells that express both IL-17RA and IL-17RE receptor chains.Here we identify genes induced in response to IL-17C treatment of human keratinocytes to provide the tools for dissection of the IL-17C signaling pathway.
Keywords: NCBI GEO expression profiling by array
73
Human peripheral blood cells: systemic lupus erythem...
Gene expression profiling of peripheral blood cells from patients with systemic lupus erythematosus (SLE) vs healthy individual (HI).
Keywords: NCBI GEO expression profiling by array
74
IFNalpha kinoid induces neutralizing anti-IFNalpha a...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
75
IL-17A is an essential cytokine to sustain pathogeni...
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies in model systems indicate that IL-22 has a dominant pathogenic role, there is evolving evidence that IL-17 contributes to features of psoriasis. To more fully understand the role of IL-17 in human ...
Keywords: NCBI GEO expression profiling by array
76
ImmGen Microarray Phase 1
Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. Data is released monthly in batches of cell populations.
Keywords: NCBI GEO macrophages expression profiling by array
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Immunity and Defense Genes in Peripheral Blood Monon...
Large-scale gene expression profiling of peripheral blood mononuclear cells from Rheumatoid Arthritis (RA) patients could provide a molecular description that reflects the contribution of diverse cellular responses associated with this disease. The aim of our study is to identify peripheral blood gene expression profiles for RA patients, using Illumina technology, to gain insights into RA molecular mechanisms. The Illumina Human-6v2 Expression BeadChips were used for a complete genome-wide tr...
Keywords: NCBI GEO expression profiling by array
78
Inflammatory Expression Profiles in Monocyte to Macr...
To examine mononuclear cell gene expression profiles in patients with and without SLE and subsets with and without atherosclerosis
Keywords: NCBI GEO expression profiling by array
79
Integrated Network and Microarray Analysis to Identi...
A significant proportion of acute myocardial infarction (MI) patients develop heart failure (HF). Early identification of patients at risk of developing HF after MI would be a major breakthrough. An approach combining the power of biological information networks and the precision of microarray analysis was undertaken to identify biomarkers of HF. A set of three new biomarkers of HF was identified and provided significantly improved prediction accuracy than microarray or network analysis alone...
Keywords: NCBI GEO expression profiling by array
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