Data Catalog

Expression data from affected skin from psoriasis mo...

Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. In this study, whole-genome transcriptional profiling is used to compare gene expression p...

Keywords: NCBI GEO expression profiling by array

Project website

Expression data from airway epithelial cells from pa...

The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium.We used micro array to profile gene expression of primary nasal and bronchial epithelial cells from the same individuals and ex...

Keywords: NCBI GEO expression profiling by array

Project website

Expression data from asthmatic and healthy airway s...

Persistent severe asthma is associated with hyper-contractile airways and structural changes in the airway wall, including an increased airway smooth muscle (ASM) mass. This study used gene expression profiles from asthmatic and healthy airway smooth muscle cells grown in culture to identify novel receptors and pathways that potentially contributed to asthma pathogenesis.We used microarrays to compare the gene expression between asthmatic and healthy airway smooth muscle cells to understand t...

Keywords: NCBI GEO expression profiling by array

Project website

Expression data from human bronchial airway smooth m...

Interleukin (IL)-17 plays an important and protective role in host defence and has been demonstrated to orchestrate airway inflammation by cooperating with and inducing proinflammatory cytokines. Mircoarrays were used to identify immediate-early/ primary response IL-17A-dependent gene transcripts in primary human bronchial ASM cells from mild asthmatic and healthy individuals.

Keywords: NCBI GEO expression profiling by array

Project website

Expression data from human macrophages

Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 4, 12, 24, 72 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ng/ml) or left without activation. Simultaneously, macrophages were also treated with vehicle (DMSO:ethanol) or 1mM synthetic PPARg agonist, Rosiglitazone. We used Affymetrix microarrays (U133Plus ...

Keywords: NCBI GEO macrophages expression profiling by array

Project website

Expression data from human with lupus nephritis (LN)

Nephritis (LN) is a serious manifestation of SLE. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these models. In this study we used an unbiased transcriptional network approach to define similarities and differences between three lupus models and human LN. Affymetrix-based expression profiles were analyzed using Genomatix Bibliosphere software and transcriptional networks were compared using the...

Keywords: NCBI GEO expression profiling by array

Project website

Expression data from intestinal mucosa of patients with UC

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with preiods of active disease followed by remission.We performed a whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, as well as non-inflammatory controls.

Keywords: NCBI GEO expression profiling by array