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185 projects found
Lung biopsies from asthmatics pre- and post- steroid...
To better understand the therapeutic potential of targeting Th2 inflammation in asthma, we performed genome-wide expression profiling of endobronchial biopsies in asthmatics and healthy controls stratified according a previously defined three-gene Th2 signature in bronchial epithelium.The Th2 signature is defined as relatively high expression of POSTN, CLCA1, and SERPINB2.
Keywords: NCBI GEO expression profiling by array
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Combination of peripheral blood gene expression prof...
We used microarrays to identify markers predicting responder status in tocilizumab treatment in rheumatoid arthritis in 13 patients at week 0 and week 4 of treatment.
Keywords: NCBI GEO expression profiling by array
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Expression data for human epithelium from subjects w...
The expression and function of tight junction genes, in particular claudin-1, was studied in order to further understanding of the biology underlying atopic dermatitis.
Keywords: NCBI GEO expression profiling by array
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Mechanisms Establishing TLR4-Responsive Activation S...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO macrophages expression profiling by array genome binding/occupancy profiling by high throughput sequencing expression profiling by high throughput sequencing
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Genomic predictor of response and survival following...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
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IL-17A is an essential cytokine to sustain pathogeni...
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies in model systems indicate that IL-22 has a dominant pathogenic role, there is evolving evidence that IL-17 contributes to features of psoriasis. To more fully understand the role of IL-17 in human ...
Keywords: NCBI GEO expression profiling by array
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Expression data from lupus NZB/W, NZM2410, NZW/BXSB ...
Nephritis (LN) is a serious manifestation of SLE. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these models. In this study we used an unbiased transcriptional network approach to define similarities and differences between three lupus models and human LN. Affymetrix-based expression profiles were analyzed using Genomatix Bibliosphere software and transcriptional networks were compared using the...
Keywords: NCBI GEO expression profiling by array
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A single intradermal injection of IFN-γ induces a ps...
psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-γ is involved in many cellular processes, including activation of T cells and dendritic cells (DCs), antigen processing and presentation, cell adhesion and trafficking, and cytokine and chemokine production, IFN-γ-producing Th1 cells were proposed to be integral to the pathogenesis of psoriasis. Recently, IFN-γ was shown to enhance IL-23 and IL-1 production by DCs and subsequently induce Th17 cells, import...
Keywords: NCBI GEO expression profiling by array
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