Search projects
185 projects found
Type I Interferon: Potential Therapeutic Target for ...
We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. Concordant overexpression of IFN-c and TNF-a–inducible gene signatures occ...
Keywords: Affymetrix Human Genome U133 Plus 2.0 array expression profiling by array
9
Differential effects of TNFalpha and IL1beta on FLS ...
TNFalpha and IL1beta play a pathogenic role in rheumatoid arthritis. Both cytokines are known to activate cytokine and metalloproteinase secretion by synovial fibroblasts. In the present study, we wanted to investigate whether TNFalpha and IL1beta displayed differential effects on cultured Fibroblast-like Synovial Cells derived from RA patients. Global gene expression analyses indicated that both cytokines induced similar genes in these cells.
Keywords: NCBI GEO expression profiling by array
10
ImmGen Microarray Phase 1
Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. Data is released monthly in batches of cell populations.
Keywords: NCBI GEO macrophages expression profiling by array
11
Transcriptional analysis of multiple brain regions i...
Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms.This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
12
Systematic meta-analysis and replication of genome-w...
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.Analysis of substantia nigrae from postmortem brains of 6 patients with Parkinson's disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.
Keywords: NCBI GEO expression profiling by array
13
Systematic meta-analysis and replication of genome-w...
Analysis of substantia nigra from postmortem brains of 4 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.
Keywords: NCBI GEO expression profiling by array
14
Systematic meta-analysis and replication of genome-w...
Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.Examination of substantia nigra from postmortem brains of 8 patients with Parkinson's disease (PD).
Keywords: NCBI GEO expression profiling by array
15
Transcriptional analysis of whole substantia nigra i...
Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects
Keywords: NCBI GEO expression profiling by array
16
