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185 projects found
Human colon expression in healthy controls, colon-on...
Colon gene expression in human IBD. The three major clinical subsets of Inflammatory Bowel Disease (IBD) include colon-only Crohn's Disease (CD), ileo-colonic CD, and Ulcerative Colitis (UC). These experiments tested differential colon gene expression in these three types of IBD, relative to healthy control samples, and the local degree of mucosal inflammation as measured by the CD Histological Index of Severity (CDHIS). Colon biopsy samples were obtained from IBD patients at diagnosis and d...
Keywords: Single time point in CD and UC and healthy controls. expression profiling by array
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Integrated Network and Microarray Analysis to Identi...
A significant proportion of acute myocardial infarction (MI) patients develop heart failure (HF). Early identification of patients at risk of developing HF after MI would be a major breakthrough. An approach combining the power of biological information networks and the precision of microarray analysis was undertaken to identify biomarkers of HF. A set of three new biomarkers of HF was identified and provided significantly improved prediction accuracy than microarray or network analysis alone...
Keywords: NCBI GEO expression profiling by array
90
Identification of markers of responsiveness in rheum...
Despite the increasing of available drugs in RA, the overall rate of non response is 30 to 40% of treated patients. To optimize the drug prescription and better elaborate the therapeutic strategies, gene profiling in PBMCs was used to predict the responsiveness to anakinra. Thirty two patients treated by anakinra (100mg/day s.c.) and méthotrexate, were categorized as responders whenever a change of Disease Activity Score 28 > 1.2 was obtained at 3 months. Blood from treated patients was colle...
Keywords: anakinra effect expression profiling by array
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Microarray predictor of response to infliximab in rh...
We sought to find a gene-expression multigene predictor of response to infliximab therapy in Rheumatoid Arthritis patients. Using internal and external cross-validation systems we have built and validated an 8-gene predictor for response to infliximab.
Keywords: NCBI GEO expression profiling by array
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A modular analysis framework for the discovery of bi...
Transcriptional modules were used as a basis for the selection of biomarkers and the development of a multivariate transcriptional indicator of disease progression in patients with systemic lupus erythematosus.
Keywords: NCBI GEO expression profiling by array
93
Expression data from human colonic biopsy sample
Gene expression profile based classification of colonic diseases are suitable for identification of diagnostic mRNA expression patterns which can establish the basis of a new molecular biological diagnostic method
Keywords: whole genomic expression expression profiling by array
94
Gene expression in rheumatoid arthritis synovial macrophages
Macrophages from RA synovial fluids were compared to primary human blood-derived macrophages.
Keywords: disease state analysis expression profiling by array
95
Whole transcriptome analysis of the hippocampus: tow...
Purpose: to evaluate changes in the transcriptome of hippocampal cells during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures.Experimental Design: Gene expression profiling was analyzed in hippocampi of rats subjected to the pilocarpine model of epilepsy at different times during the course of epileptogenesis: 3 days post-SE (3D), 7 days post-SE (7D), and immediately (up to 12h) after the first spontaneous seizur...
Keywords: gene expression changes during epileptogenesis. expression profiling by array
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