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19 projects found
Gene expression profiling of human monocytes and mon...
In this study we analyzed the gene expression profiles of human monocytes and monocyte-dervied-macrophages.
Keywords: Gene expression profiling macrophages expression profiling by array
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Time course of bone marrow-derived macrophages simul...
The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-κB, C/EBPδ, and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally v...
Keywords: NCBI GEO macrophages expression profiling by array
2
ImmGen Microarray Phase 1
Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. Data is released monthly in batches of cell populations.
Keywords: NCBI GEO macrophages expression profiling by array
3
Peritoneal and testicular macrophage mrna expression...
Ascending bacterial infections of the male genitourinary tract by Escherichia coli are an important cause of male infertility. Thus understanding mechanisms by which immunocompetent cells such as testicular macrophages (TM) respond to infection and how bacterial pathogens manipulate defense pathways is of great relevance. Following infection with uropathogenic E. coli (UPEC) whole genome expression profiling revealed induction of the calcium-dependent nuclear factor of activated T cells (NFAT...
Keywords: NCBI GEO macrophages expression profiling by array
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Mechanisms Establishing TLR4-Responsive Activation S...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO macrophages expression profiling by array genome binding/occupancy profiling by high throughput sequencing expression profiling by high throughput sequencing
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Human immune cell transcriptome
In the present study we used Affymetrix oligonucleotide microarrays to produce gene transcription profiles for the major leukocyte types in humans. This comprehensive dataset enabled us to not only establish which genes were expressed in each leukocyte type, but also which genes were expressed in each subset after activation. The used of a comprehensive dataset of gene profiles from all the major human leukocyte subsets enabled a novel and powerful means for identification of genes associated...
Keywords: Cell type comparison macrophages expression profiling by array
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Expression Data from Macrophage Maturation and Polar...
Monocytes were induced to mature to macrophages with M-CSF. Cells were then activated with Interferon gamma and LPS or IL-4.
Keywords: NCBI GEO macrophages expression profiling by array
7
Circulating Mononuclear Cell Transcriptomes in Patie...
Monocytes and T-cells play an important role in the development of atherosclerotic coronary artery disease (CAD). Differences in transcriptional activity of these cells might reflect the individual's atherosclerotic burden. Transcriptome analysis of circulating mononuclear cells from carefully matched atherosclerotic and control patients will potentially provide insights into the pathophysiology of atherosclerosis and supply biomarkers for diagnostic purposes. From patients undergoing coron...
Keywords: disease-state analysis macrophages expression profiling by array
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