Search projects
6 projects found
Parkinson's disease vs. controls, whole blood
Parkinson’s disease (PD) progresses relentlessly and affects five million people worldwide. Laboratory tests for PD are critically needed for developing treatments designed to slow or prevent progression of the disease. We performed a transcriptome-wide scan in 105 individuals to interrogate the molecular processes perturbed in cellular blood of patients with early-stage PD. The molecular marker here identified is strongly associated with risk of PD in 66 samples of the training set (third te...
Keywords: disease state analysis expression profiling by array
1
Strong Time Dependence of the 76-Gene Prognostic Signature
Background: Recently a 76-gene prognostic signature able to predict distant metastases in lymph node-negative (N-) breast cancer patients was reported. The aims of this study conducted by TRANSBIG were to independently validate these results and to compare the outcome with clinical risk assessment. Materials and Methods: Gene expression profiling of frozen samples from 198 N- systemically untreated patients was performed at the Bordet Institute, blinded to clinical data and independent of Ver...
Keywords: disease state analysis expression profiling by array
2
Gene expression in rheumatoid arthritis synovial macrophages
Macrophages from RA synovial fluids were compared to primary human blood-derived macrophages.
Keywords: disease state analysis expression profiling by array
3
Gene expression data of skin from psoriatic patients...
Gene expression has been proposed as an intermediate phenotype that can increase power in complex trait gene-mapping studies. Psoriasis, an immune-mediated, inflammatory and hyperproliferative disease of the skin and joints, provides an ideal model system to evaluate this paradigm, as conclusive evidence demonstrates that psoriasis has a genetic basis and the disease tissue is readily accessible.To better understand the complex nature of processes in psoriasis, we characterize gene expression...
Keywords: disease state analysis expression profiling by array
4
Genome-Wide Profiling of Airway Epithelial Cells in ...
We collected airway epithelial brushings for microarray analysis from 42 asthmatics and two control groups – 28 healthy subjects and 16 smokers. A subgroup of 32 asthmatics completed a randomized placebo-controlled trial of fluticasone propionate in which collection of brushings was repeated after 1 week of treatment.
Keywords: disease state analysis clinical trial expression profiling by array
5
Expression data of synovial cells isolated from pati...
Rheumatoid arthritis (RA), a chronic and systemic disease of unknown etiology, is characterized by hyperplasia of synovial cells, which ultimately lead to the destruction of cartilage and bone. To elucidate the molecular mechanisms that lead to RA, we analyzed synovial cells established from patient with RA by oligonucleotide microarrays. Gene expression profiles reveal a novel pathophysiologic function of RA synovial cells as a generator of oxidative stress, and a self-defense mechanism ag...
Keywords: cell type comparison disease state analysis expression profiling by array
6
