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142 projects found
Expression data from intestinal mucosa of patients with UC
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with preiods of active disease followed by remission.We performed a whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, as well as non-inflammatory controls.
Keywords: NCBI GEO expression profiling by array
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Human Rheumatoid Arthritis Synovial Fibroblasts: Con...
Transcriptional profiling of human rheumatoid arthritis synovial fibroblasts comparing control cells treated with BSA with cells treated with Tenascin-C.
Keywords: NCBI GEO expression profiling by array
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To identify gene markers which differentiate between...
Aspirin-exacerbated respiratory disease (AERD) has association with severe asthma and aspirin can cause asthma to worsen, often in the form of a severe and sudden attack. The oral aspirin challenge (OAC) is the gold standard to confirm the diagnosis of AERD but it is time consuming and produces serious complications in some cases. Therefore more efficient and practical method is needed to predict AERD patients. The aim of the present study was to identify AERD-related gene expression in perip...
Keywords: NCBI GEO expression profiling by array
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Repeated observation of breast tumor subtypes in ind...
Abstract: Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant subgroups. In this study, we have refined the previously defined subtypes of breast tumors that could be distinguished by their distinct patterns of gene expression. A total of 115 malignant breast tumors were analyzed by hierarchical clustering based on patterns of expression of 534 "intrinsic" genes and shown to subdivide into one basal-like, one ERBB2-...
Keywords: NCBI GEO expression profiling by array
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Gene expression alterations in the cerebellum and gr...
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized the cystatin B deficient mice (Cstb-/-), a model for the disease. We have characterized the gene expression changes from the cerebellum of Cstb-/- mouse at postnatal day 7 (P7) and P30 as well as i...
Keywords: NCBI GEO expression profiling by array
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Asthmatics with exacerbation during acute respirator...
Acute respiratory illness (ARI) is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular mechanisms driving ARI-induced asthma exacerbations, we undertook a transcriptional profiling study of the nasal mucosa over the course of ARI amongst individuals with a history of asthma, allergic rhinitis and no underlying respiratory disease. We found that ARI is characterized by dynamic...
Keywords: NCBI GEO expression profiling by array
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Expression data from airway epithelial cells from pa...
The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium.We used micro array to profile gene expression of primary nasal and bronchial epithelial cells from the same individuals and ex...
Keywords: NCBI GEO expression profiling by array
47
The peroxisome proliferator-activated receptor-gamma...
Previous studies indicate that peroxisome proliferator-activated receptor-gamma (PPAR-g) agonists suppress autoimmune responses and renal inflammation in murine lupus. However, the mechanisms implicated in this process remain unclear. We tested the effect of the PPAR-g agonist pioglitazone in human lupus and control PBMCs with regards to gene regulation and various functional assays.We used microarrays to analyze the effect of Pioglitazone on peripheral blood cells (PBMCs) from healthy and lu...
Keywords: NCBI GEO expression profiling by array
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