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142 projects found
Gene Expression Profiles in a Rabbit Model of System...
We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model of Systemic Lupus Erythematosus (SLE) in which peptide immunization led to lupus-like autoantibody production including anti-Sm, -RNP, -SS-A, -SS-B and -dsDNA. Some neurological symptoms in form of seizures and nystagmus were observed. The animals used in the previous and in the present study were from a National Institute of Allergy and Infectious Diseases colony of rabbits that were pedigreed, immunoglobulin...
Keywords: NCBI GEO expression profiling by array
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Peritoneal and testicular macrophage mrna expression...
Ascending bacterial infections of the male genitourinary tract by Escherichia coli are an important cause of male infertility. Thus understanding mechanisms by which immunocompetent cells such as testicular macrophages (TM) respond to infection and how bacterial pathogens manipulate defense pathways is of great relevance. Following infection with uropathogenic E. coli (UPEC) whole genome expression profiling revealed induction of the calcium-dependent nuclear factor of activated T cells (NFAT...
Keywords: NCBI GEO macrophages expression profiling by array
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Expression data from advanced Parkinson's disease (P...
Sub-thalamic deep brain stimulation (DBS) reversibly modulates Parkinson’s disease (PD) motor symptoms, providing an unusual opportunity to compare leukocyte transcripts in the same subjects before and after neurosurgery and after disconnecting the stimulus (ON-and OFF-stimulus). Here, we report rapid stimulus-induced and largely reversible changes in PD leukocyte transcripts, which were larger in scope than the disease-induced changes. These transcript changes classified advanced pre- from p...
Keywords: NCBI GEO expression profiling by array
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Polyglutamine Atrophin provokes neurodegeneration in...
Dentatorubral-pallidoluysian Atrophy (DRPLA) is a human polyQ disease caused by the expansion of a CAG strech in the atrophin-1 (at-1) gene. In all vertebrates, a second atrophin gene (at-2) is present and it encodes a related protein void of polyQ tracks. In D.melanogaster there is one conserved Atrophin (Atro) gene, ubiquitously expressed, which contains all functional domains of vertebrate Atrophins, including two polyQ stretches. To understand to what extent transcriptional alterations ca...
Keywords: NCBI GEO expression profiling by array
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Lung biopsies from asthmatics pre- and post- steroid...
To better understand the therapeutic potential of targeting Th2 inflammation in asthma, we performed genome-wide expression profiling of endobronchial biopsies in asthmatics and healthy controls stratified according a previously defined three-gene Th2 signature in bronchial epithelium.The Th2 signature is defined as relatively high expression of POSTN, CLCA1, and SERPINB2.
Keywords: NCBI GEO expression profiling by array
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Combination of peripheral blood gene expression prof...
We used microarrays to identify markers predicting responder status in tocilizumab treatment in rheumatoid arthritis in 13 patients at week 0 and week 4 of treatment.
Keywords: NCBI GEO expression profiling by array
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Expression data for human epithelium from subjects w...
The expression and function of tight junction genes, in particular claudin-1, was studied in order to further understanding of the biology underlying atopic dermatitis.
Keywords: NCBI GEO expression profiling by array
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Mechanisms Establishing TLR4-Responsive Activation S...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO macrophages expression profiling by array genome binding/occupancy profiling by high throughput sequencing expression profiling by high throughput sequencing
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