Search projects
142 projects found
Human Rheumatoid Arthritis Synovial Fibroblasts: Con...
Transcriptional profiling of human rheumatoid arthritis synovial fibroblasts comparing control cells treated with BSA with cells treated with Tenascin-C.
Keywords: NCBI GEO expression profiling by array
73
Human bone marrow-derived mononuclear cells (BMMC): ...
Gene expression profiling of BMMC from patients with rheumatoid arthritis (RA) vs. osteoarthritis (OA).
Keywords: NCBI GEO expression profiling by array
74
Human keratinocytes have a response to injury that u...
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive immune responses, e.g. CCL20, in their early state of activation without signals from infiltrating T cells. This study aims to isolate the immediate alterations in protective and inflammatory gene ...
Keywords: NCBI GEO expression profiling by array
75
Human keratinocytes stimulated with IL-17C
IL-17C is important for the pathogenesis of inflammatory diseases such as IBD and psoriasis. We found that IL-17C is highly induced in a murine model of psoriasis. Recent results suggest that IL-17C can target epithelial cells that express both IL-17RA and IL-17RE receptor chains.Here we identify genes induced in response to IL-17C treatment of human keratinocytes to provide the tools for dissection of the IL-17C signaling pathway.
Keywords: NCBI GEO expression profiling by array
76
Human peripheral blood cells: systemic lupus erythem...
Gene expression profiling of peripheral blood cells from patients with systemic lupus erythematosus (SLE) vs healthy individual (HI).
Keywords: NCBI GEO expression profiling by array
77
Human rhinovirus infection causes different DNA meth...
Background: Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. Objective: To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA methylation profiling in asthmatic and healthy nasal epithelial cells (NECs) during Human Rhinovirus (HRV) infection in vitro. Methods: Global and loci-specific methylation profiles were determined via Alu element and Infinium Human Methylation 450K microarray respect...
Keywords: NCBI GEO methylation profiling by genome tiling array
78
IFNalpha kinoid induces neutralizing anti-IFNalpha a...
This SuperSeries is composed of the SubSeries listed below.
Keywords: NCBI GEO expression profiling by array
79
IL-17A is an essential cytokine to sustain pathogeni...
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies in model systems indicate that IL-22 has a dominant pathogenic role, there is evolving evidence that IL-17 contributes to features of psoriasis. To more fully understand the role of IL-17 in human ...
Keywords: NCBI GEO expression profiling by array
80
