Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR
c7515074-b34a-11eb-9969-acde48001122
Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. The dataset developed in this project provides matched genotyping and DNA methylation data in four tissues (ileum, rectum, T-cells, B-cells) from healthy individuals. Using this data, we demonstrate the discrimination of common from cell-type-specific methQTLs. Our analysis demonstrates that a systematic analysis of methQTLs provides important new insights on the influences of genetic variants to cell-type-specific epigenomic variation.
- Project Title
- SYSCID
- Project website
- http://syscid.eu/
- Primary Purpose
- Identification of methylation quantitative trait loci
- Description of Cohorts
- Healthy Individuals
- Informed Consent Given?
- True
- Multi-center Study?
- False
- Organisms
- Homo sapiens
- Number of subjects
- 345
- Sample Sources
- tissue sample
- Type of Samples Collected
- blood transverse colon CD14+ monocytes ileum CD19+ B-cells CD4+ T-cells rectum
- Cohort characteristics
-
15.94-42.7217-86 year
